Het-PDB Navi2 (PDB: 5VK1)

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Ligands
Code	Name		Style	Show	Link

Non-standard Residues
Code	Name	Show
9E7	N~6~-(sulfanylmethyl)-L-lysine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group
NH2	Amino group

Download interaction data: 5VK1

Code :

5VK1 PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN/INHIBITOR

Title :

Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI

Release Data :

2018-04-25

Compound :

mol_id	molecule	chains	synonym
1	Protein Mdm4	A,C,E,G,I,K,M,O	Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4
	fragment: residues 24-108 mutation: Q68A, Q69A, E70A

mol_id	molecule	chains
2	Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI	B,D,F,H,J,L,N,P

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	synthetic: yes

mol_id	organism_scientific
2	Synthetic construct (taxid:32630)
	synthetic: yes

Authors :

Tolbert, W.D., Gohain, N., Pazgier, M.

Keywords :

MDMX, MDMX-PEPTIDE INHIBITOR COMPLEX, ONCOPROTEIN, METAL-BINDING, NUCLEUS, ZINC-FINGER, stapled peptide, SIGNALING PROTEIN-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.69 Å )

Citation :

Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.

Li, X.,Tolbert, W.D.,Hu, H.G. et al.
(2019) Chem Sci 10 : 1522 - 1530

PDB ID: 5VK1