PDB ID: 4FRS
Hetero Atom Contents
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Structure summary
Code : | 4FRS PDBj RCSB PDB PDBe | ||||||||||||
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Header : | Hydrolase/Hydrolase inhibitor | ||||||||||||
Title : | Structure of BACE in complex with (S)-4-(3-chloro-5-(5-(prop-1-yn-1-yl)pyridin-3-yl)thiophen-2-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-iminium | ||||||||||||
Release Data : | 2012-08-08 | ||||||||||||
Compound : |
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Source : |
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Authors : | Orth, P. | ||||||||||||
Keywords : | Alzheimer's, Aspartyl protease, Hydrolase, Hydrolase-Hydrolase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.7000 Å ) | ||||||||||||
Citation : |
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS A(beta) Reduction
Stamford, A.W.,Scott, J.D.,Li, S.W.
et al.
PubMed: 23412139 |
Reaction
Chain : | A, B |
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UniProt : | P56817 (BACE1_HUMAN) |
Reaction : | Reaction=Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|- Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.; EC=3.4.23.46; Evidence={ECO:0000269|PubMed:10677483}; |