ID 4FRSA STANDARD; PRT; 395 AA. DT CONVERTED FROM PDB (SEQRES) 4FRS DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.700 CC R-Factor 0.202 FT #SUB 248 300 LYS A 114 166 SER B Protein S 1 FT #SUB 248 300 LYS A 115 167 ASP B Protein S 6 FT #SUB 248 300 LYS A 116 168 LYS B Protein S 2 FT #SUB 251 303 GLU A 113 165 GLU B Protein S 8 FT #SUB 255 307 LYS A 77 129 TYR B Protein S 5 FT #SUB 255 307 LYS A 86 138 GLU B Protein S 4 FT #HET 19 71 SER A 1 501 0V6 A B 2 FT #HET 21 73 GLN A 1 501 0V6 A B 3 FT #HET 22 74 GLY A 1 501 0V6 A B 6 FT #HET 39 91 LEU A 1 501 0V6 A S 2 FT #HET 41 93 ASP A 1 501 0V6 A S 11 FT #HET 43 95 GLY A 1 501 0V6 A B 2 FT #HET 44 96 SER A 1 501 0V6 A S 2 FT #HET 80 132 TYR A 1 501 0V6 A S 11 FT #HET 82 134 GLN A 1 501 0V6 A S 9 FT #HET 83 135 GLY A 1 501 0V6 A B 2 FT #HET 117 169 PHE A 1 501 0V6 A S 2 FT #HET 124 176 TRP A 1 501 0V6 A S 3 FT #HET 237 289 ASP A 1 501 0V6 A S 5 FT #HET 238 290 SER A 1 501 0V6 A B 2 FT #HET 239 291 GLY A 1 501 0V6 A B 12 FT #HET 240 292 THR A 1 501 0V6 A A 3 FT #HET 344 396 ALA A 1 501 0V6 A S 1 FT DISORDER 1 5 FT DISORDER 321 323 FT DISORDER 395 395 CC SEQUENCE 386 AA (ATOM); CC GSFVEMVDNL RGKSGQGYYV EMTVGSPPQT LNILVDTGSS NFAVGAAPHP FLHRYYQRQL CC SSTYRDLRKG VYVPYTQGKW EGELGTDLVS IPHGPNVTVR ANIAAITESD KFFINGSNWE CC GILGLAYAEI ARPDDSLEPF FDSLVKQTHV PNLFSLQLCG AGFPLNQSEV LASVGGSMII CC GGIDHSLYTG SLWYTPIRRE WYYEVIIVRV EINGQDLKMD CKEYNYDKSI VDSGTTNLRL CC PKKVFEAAVK SIKAASSTEK FPDGFWLGEQ LVCWQAGTTP WNIFPVISLY LMGEVTNQSF CC RITILPQQYL RPVEDSQDDC YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC CC HVHDEFRTAA VEGPFVTLDM EDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES EPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG CC ATOM -----GSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG CC ********************************************* CC SEQRES AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGP CC ATOM AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGP CC ************************************************** CC SEQRES NVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLV CC ATOM NVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLV CC ************************************************** CC SEQRES KQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYT CC ATOM KQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYT CC ************************************************** CC SEQRES PIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVF CC ATOM PIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVF CC ************************************************** CC SEQRES EAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV CC ATOM EAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV CC ************************************************** CC SEQRES TNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGF CC ATOM TNQSFRITILPQQYLRPVED---SQDDCYKFAISQSSTGTVMGAVIMEGF CC ******************** *************************** CC SEQRES YVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI CC ATOM YVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN- CC ******************************************** SQ SEQUENCE 395 AA; MW; CN; EPGRRGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNI // ID 4FRSB STANDARD; PRT; 395 AA. DT CONVERTED FROM PDB (SEQRES) 4FRS DE Beta-secretase 1 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.700 CC R-Factor 0.202 FT #SUB 77 129 TYR B 255 307 LYS A Protein S 5 FT #SUB 86 138 GLU B 255 307 LYS A Protein S 4 FT #SUB 113 165 GLU B 251 303 GLU A Protein S 8 FT #SUB 114 166 SER B 248 300 LYS A Protein B 1 FT #SUB 115 167 ASP B 248 300 LYS A Protein A 6 FT #SUB 116 168 LYS B 248 300 LYS A Protein A 2 FT #HET 19 71 SER B 2 501 0V6 B B 2 FT #HET 21 73 GLN B 2 501 0V6 B B 3 FT #HET 22 74 GLY B 2 501 0V6 B B 6 FT #HET 39 91 LEU B 2 501 0V6 B S 2 FT #HET 41 93 ASP B 2 501 0V6 B S 11 FT #HET 43 95 GLY B 2 501 0V6 B B 3 FT #HET 44 96 SER B 2 501 0V6 B S 2 FT #HET 80 132 TYR B 2 501 0V6 B S 11 FT #HET 82 134 GLN B 2 501 0V6 B A 5 FT #HET 83 135 GLY B 2 501 0V6 B B 2 FT #HET 117 169 PHE B 2 501 0V6 B S 2 FT #HET 119 171 ILE B 2 501 0V6 B S 1 FT #HET 124 176 TRP B 2 501 0V6 B S 3 FT #HET 237 289 ASP B 2 501 0V6 B S 5 FT #HET 238 290 SER B 2 501 0V6 B B 2 FT #HET 239 291 GLY B 2 501 0V6 B B 12 FT #HET 240 292 THR B 2 501 0V6 B A 3 FT #HET 241 293 THR B 2 501 0V6 B A 3 FT #HET 344 396 ALA B 2 501 0V6 B S 1 FT DISORDER 1 4 FT DISORDER 321 323 FT DISORDER 395 395 CC SEQUENCE 387 AA (ATOM); CC RGSFVEMVDN LRGKSGQGYY VEMTVGSPPQ TLNILVDTGS SNFAVGAAPH PFLHRYYQRQ CC LSSTYRDLRK GVYVPYTQGK WEGELGTDLV SIPHGPNVTV RANIAAITES DKFFINGSNW CC EGILGLAYAE IARPDDSLEP FFDSLVKQTH VPNLFSLQLC GAGFPLNQSE VLASVGGSMI CC IGGIDHSLYT GSLWYTPIRR EWYYEVIIVR VEINGQDLKM DCKEYNYDKS IVDSGTTNLR CC LPKKVFEAAV KSIKAASSTE KFPDGFWLGE QLVCWQAGTT PWNIFPVISL YLMGEVTNQS CC FRITILPQQY LRPVEDSQDD CYKFAISQSS TGTVMGAVIM EGFYVVFDRA RKRIGFAVSA CC CHVHDEFRTA AVEGPFVTLD MEDCGYN CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES EPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG CC ATOM ----RGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVG CC ********************************************** CC SEQRES AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGP CC ATOM AAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGP CC ************************************************** CC SEQRES NVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLV CC ATOM NVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLV CC ************************************************** CC SEQRES KQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYT CC ATOM KQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYT CC ************************************************** CC SEQRES PIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVF CC ATOM PIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVF CC ************************************************** CC SEQRES EAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV CC ATOM EAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV CC ************************************************** CC SEQRES TNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGF CC ATOM TNQSFRITILPQQYLRPVED---SQDDCYKFAISQSSTGTVMGAVIMEGF CC ******************** *************************** CC SEQRES YVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI CC ATOM YVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN- CC ******************************************** SQ SEQUENCE 395 AA; MW; CN; EPGRRGSFVE MVDNLRGKSG QGYYVEMTVG SPPQTLNILV DTGSSNFAVG AAPHPFLHRY YQRQLSSTYR DLRKGVYVPY TQGKWEGELG TDLVSIPHGP NVTVRANIAA ITESDKFFIN GSNWEGILGL AYAEIARPDD SLEPFFDSLV KQTHVPNLFS LQLCGAGFPL NQSEVLASVG GSMIIGGIDH SLYTGSLWYT PIRREWYYEV IIVRVEINGQ DLKMDCKEYN YDKSIVDSGT TNLRLPKKVF EAAVKSIKAA SSTEKFPDGF WLGEQLVCWQ AGTTPWNIFP VISLYLMGEV TNQSFRITIL PQQYLRPVED VATSQDDCYK FAISQSSTGT VMGAVIMEGF YVVFDRARKR IGFAVSACHV HDEFRTAAVE GPFVTLDMED CGYNI //