PDB ID: 4DFL
Hetero Atom Contents
color scheme of protein:
hetatm:
x
information
centroid:
interaction residue:
chain:
Structure summary
Code : | 4DFL PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor | ||||||||||||
Release Data : | 2012-04-25 | ||||||||||||
Compound : |
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Source : |
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Authors : | Lopez, M., Segarra, V., Vidal, B., Wenzkowski, C., Jestel, A., Krapp, S., Blaesse, M., Nagel, S., Schreiner, P. | ||||||||||||
Keywords : | SYK, TRANSFERASE, KINASE, INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.98 Å ) | ||||||||||||
Citation : |
Pyrazine-based Syk kinase inhibitors.
Forns, P.,Esteve, C.,Taboada, L.
et al.
PubMed: 22425453 |
Reaction
Chain : | A |
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UniProt : | P43405 (KSYK_HUMAN) |
Reaction : | Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028}; |