PDB ID: 3O95
Hetero Atom Contents
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Structure summary
Code : | 3O95 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE,SIGNALING PROTEIN/INHIBITOR | ||||||||||||
Title : | Crystal Structure of Human DPP4 Bound to TAK-100 | ||||||||||||
Release Data : | 2011-01-26 | ||||||||||||
Compound : |
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Source : |
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Authors : | Yano, J.K., Aertgeerts, K. | ||||||||||||
Keywords : | protease and 8-bladed beta-propeller domain, Aminopeptidase, Cell membrane, Glycoprotein, Hydrolase, Membrane, Protease, Secreted, Serine protease, Signal-anchor, Transmembrane, SIGNALING PROTEIN, SIGNALING PROTEIN-INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.8500 Å ) | ||||||||||||
Citation : |
Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor.
Miyamoto, Y.,Banno, Y.,Yamashita, T.
et al.
PubMed: 21218817 |
Reaction
Chain : | A, B, C, D |
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UniProt : | P27487 (DPP4_HUMAN) |
Reaction : | Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.; EC=3.4.14.5; Evidence={ECO:0000255|PROSITE- ProRule:PRU10084, ECO:0000269|PubMed:10593948}; |