ID 3O95A STANDARD; PRT; 740 AA. DT CONVERTED FROM PDB (SEQRES) 3O95 DE Dipeptidyl peptidase 4 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.850 CC R-Factor 0.190 FT #SUB 208 234 PRO A 222 248 TYR B Protein S 8 FT #SUB 209 235 LEU A 222 248 TYR B Protein B 2 FT #SUB 210 236 ILE A 223 249 PRO B Protein S 1 FT #SUB 211 237 GLU A 213 239 SER B Protein B 1 FT #SUB 211 237 GLU A 225 251 THR B Protein S 6 FT #SUB 211 237 GLU A 227 253 ARG B Protein S 3 FT #SUB 212 238 TYR A 213 239 SER B Protein B 1 FT #SUB 213 239 SER A 211 237 GLU B Protein S 1 FT #SUB 213 239 SER A 212 238 TYR B Protein S 1 FT #SUB 215 241 TYR A 687 713 PHE B Protein S 1 FT #SUB 215 241 TYR A 688 714 GLN B Protein S 4 FT #SUB 215 241 TYR A 691 717 ALA B Protein S 2 FT #SUB 215 241 TYR A 692 718 GLN B Protein A 3 FT #SUB 216 242 SER A 692 718 GLN B Protein B 4 FT #SUB 216 242 SER A 695 721 LYS B Protein B 2 FT #SUB 217 243 ASP A 692 718 GLN B Protein B 2 FT #SUB 218 244 GLU A 632 658 ARG B Protein A 5 FT #SUB 218 244 GLU A 635 661 TYR B Protein A 6 FT #SUB 218 244 GLU A 661 687 THR B Protein S 2 FT #SUB 218 244 GLU A 663 689 MET B Protein S 7 FT #SUB 218 244 GLU A 692 718 GLN B Protein B 6 FT #SUB 220 246 LEU A 635 661 TYR B Protein B 1 FT #SUB 220 246 LEU A 688 714 GLN B Protein B 1 FT #SUB 221 247 GLN A 232 258 LYS B Protein A 9 FT #SUB 221 247 GLN A 233 259 ALA B Protein S 4 FT #SUB 221 247 GLN A 634 660 GLU B Protein S 4 FT #SUB 221 247 GLN A 635 661 TYR B Protein B 1 FT #SUB 221 247 GLN A 688 714 GLN B Protein B 4 FT #SUB 222 248 TYR A 208 234 PRO B Protein S 8 FT #SUB 222 248 TYR A 209 235 LEU B Protein S 2 FT #SUB 222 248 TYR A 230 256 TYR B Protein S 4 FT #SUB 222 248 TYR A 231 257 PRO B Protein S 2 FT #SUB 222 248 TYR A 232 258 LYS B Protein S 16 FT #SUB 222 248 TYR A 235 261 ALA B Protein S 1 FT #SUB 223 249 PRO A 210 236 ILE B Protein S 1 FT #SUB 223 249 PRO A 688 714 GLN B Protein S 6 FT #SUB 225 251 THR A 211 237 GLU B Protein A 7 FT #SUB 227 253 ARG A 211 237 GLU B Protein S 3 FT #SUB 227 253 ARG A 227 253 ARG B Protein S 5 FT #SUB 230 256 TYR A 222 248 TYR B Protein B 4 FT #SUB 231 257 PRO A 222 248 TYR B Protein B 2 FT #SUB 232 258 LYS A 221 247 GLN B Protein A 7 FT #SUB 232 258 LYS A 222 248 TYR B Protein A 11 FT #SUB 233 259 ALA A 221 247 GLN B Protein B 4 FT #SUB 235 261 ALA A 222 248 TYR B Protein S 1 FT #SUB 632 658 ARG A 218 244 GLU B Protein S 5 FT #SUB 634 660 GLU A 221 247 GLN B Protein B 4 FT #SUB 635 661 TYR A 218 244 GLU B Protein S 6 FT #SUB 635 661 TYR A 220 246 LEU B Protein S 1 FT #SUB 635 661 TYR A 221 247 GLN B Protein S 1 FT #SUB 663 689 MET A 218 244 GLU B Protein S 5 FT #SUB 687 713 PHE A 215 241 TYR B Protein S 3 FT #SUB 687 713 PHE A 708 734 TRP B Protein S 2 FT #SUB 688 714 GLN A 215 241 TYR B Protein A 6 FT #SUB 688 714 GLN A 220 246 LEU B Protein S 1 FT #SUB 688 714 GLN A 221 247 GLN B Protein S 4 FT #SUB 688 714 GLN A 223 249 PRO B Protein S 8 FT #SUB 691 717 ALA A 215 241 TYR B Protein S 3 FT #SUB 691 717 ALA A 710 736 THR B Protein A 8 FT #SUB 692 718 GLN A 215 241 TYR B Protein S 3 FT #SUB 692 718 GLN A 216 242 SER B Protein S 4 FT #SUB 692 718 GLN A 217 243 ASP B Protein S 2 FT #SUB 692 718 GLN A 218 244 GLU B Protein S 8 FT #SUB 694 720 SER A 708 734 TRP B Protein S 6 FT #SUB 694 720 SER A 710 736 THR B Protein S 2 FT #SUB 695 721 LYS A 216 242 SER B Protein S 3 FT #SUB 695 721 LYS A 217 243 ASP B Protein S 1 FT #SUB 695 721 LYS A 218 244 GLU B Protein S 1 FT #SUB 695 721 LYS A 710 736 THR B Protein S 2 FT #SUB 695 721 LYS A 711 737 ASP B Protein S 1 FT #SUB 698 724 VAL A 709 735 TYR B Protein S 2 FT #SUB 698 724 VAL A 720 746 THR B Protein A 3 FT #SUB 698 724 VAL A 721 747 ALA B Protein S 2 FT #SUB 698 724 VAL A 724 750 HIS B Protein A 2 FT #SUB 699 725 ASP A 720 746 THR B Protein A 7 FT #SUB 702 728 VAL A 724 750 HIS B Protein B 5 FT #SUB 703 729 ASP A 724 750 HIS B Protein A 3 FT #SUB 703 729 ASP A 728 754 HIS B Protein S 6 FT #SUB 703 729 ASP A 731 757 HIS B Protein S 3 FT #SUB 704 730 PHE A 707 733 MET B Protein B 1 FT #SUB 704 730 PHE A 724 750 HIS B Protein S 4 FT #SUB 704 730 PHE A 728 754 HIS B Protein B 2 FT #SUB 705 731 GLN A 705 731 GLN B Protein S 1 FT #SUB 706 732 ALA A 706 732 ALA B Protein B 7 FT #SUB 706 732 ALA A 707 733 MET B Protein S 1 FT #SUB 706 732 ALA A 708 734 TRP B Protein S 1 FT #SUB 707 733 MET A 704 730 PHE B Protein S 1 FT #SUB 707 733 MET A 706 732 ALA B Protein S 1 FT #SUB 707 733 MET A 708 734 TRP B Protein B 3 FT #SUB 708 734 TRP A 676 702 LEU B Protein S 1 FT #SUB 708 734 TRP A 687 713 PHE B Protein S 6 FT #SUB 708 734 TRP A 690 716 SER B Protein S 2 FT #SUB 708 734 TRP A 691 717 ALA B Protein S 1 FT #SUB 708 734 TRP A 694 720 SER B Protein S 5 FT #SUB 708 734 TRP A 707 733 MET B Protein S 3 FT #SUB 708 734 TRP A 708 734 TRP B Protein A 7 FT #SUB 709 735 TYR A 698 724 VAL B Protein S 2 FT #SUB 710 736 THR A 691 717 ALA B Protein S 8 FT #SUB 710 736 THR A 694 720 SER B Protein S 2 FT #SUB 710 736 THR A 695 721 LYS B Protein A 4 FT #SUB 711 737 ASP A 695 721 LYS B Protein S 1 FT #SUB 720 746 THR A 698 724 VAL B Protein A 3 FT #SUB 720 746 THR A 699 725 ASP B Protein S 2 FT #SUB 721 747 ALA A 698 724 VAL B Protein B 2 FT #SUB 724 750 HIS A 698 724 VAL B Protein S 4 FT #SUB 724 750 HIS A 702 728 VAL B Protein S 3 FT #SUB 724 750 HIS A 703 729 ASP B Protein S 2 FT #SUB 724 750 HIS A 704 730 PHE B Protein S 4 FT #SUB 728 754 HIS A 703 729 ASP B Protein A 7 FT #SUB 728 754 HIS A 704 730 PHE B Protein S 2 FT #SUB 731 757 HIS A 703 729 ASP B Protein S 3 FT #SUB 15 41 LYS A 509 535 ASP D Protein S 2 FT #SUB 15 41 LYS A 512 538 LYS D Protein S 1 FT #SUB 25 51 ASN A 14 40 ARG D Protein A 2 FT #SUB 28 54 ARG A 14 40 ARG D Protein S 1 FT #HET 60 86 SER A 3 1 NAG F B 2 FT #HET 61 87 SER A 3 1 NAG F S 3 FT #HET 99 125 ARG A 20 1 01T A S 14 FT #HET 121 147 ARG A 1 1 NAG E S 1 FT #HET 161 187 TRP A 7 1 NAG H S 4 FT #HET 161 187 TRP A 8 2 NAG H S 1 FT #HET 168 194 ILE A 5 1 NAG G S 3 FT #HET 179 205 GLU A 20 1 01T A A 8 FT #HET 180 206 GLU A 20 1 01T A A 7 FT #HET 183 209 SER A 20 1 01T A S 1 FT #HET 195 221 THR A 18 2191 NAG A S 3 FT #HET 205 231 THR A 5 1 NAG G S 7 FT #HET 205 231 THR A 6 2 NAG G S 3 FT #HET 206 232 GLU A 5 1 NAG G S 2 FT #HET 253 279 VAL A 7 1 NAG H B 1 FT #HET 282 308 GLN A 18 2191 NAG A S 1 FT #HET 283 309 GLU A 18 2191 NAG A S 3 FT #HET 293 319 ILE A 19 3211 NAG A S 2 FT #HET 323 349 SER A 19 3211 NAG A B 2 FT #HET 324 350 THR A 19 3211 NAG A B 1 FT #HET 331 357 PHE A 20 1 01T A S 2 FT #HET 521 547 TYR A 20 1 01T A S 3 FT #HET 570 596 ARG A 19 3211 NAG A S 2 FT #HET 604 630 SER A 20 1 01T A S 7 FT #HET 630 656 VAL A 20 1 01T A S 1 FT #HET 636 662 TYR A 20 1 01T A S 12 FT #HET 640 666 TYR A 20 1 01T A S 8 FT #HET 685 711 VAL A 20 1 01T A S 2 FT #HET 714 740 HIS A 20 1 01T A S 6 FT #MOD 59 85 ASN A 3 1 NAG F S FT #MOD 124 150 ASN A 1 1 NAG E S FT #MOD 193 219 ASN A 18 2191 NAG A S FT #MOD 203 229 ASN A 5 1 NAG G S FT #MOD 255 281 ASN A 7 1 NAG H S FT #MOD 295 321 ASN A 19 3211 NAG A S FT DISORDER 1 13 CC SEQUENCE 727 AA (ATOM); CC RKTYTLTDYL KNTYRLKLYS LRWISDHEYL YKQENNILVF NAEYGNSSVF LENSTFDEFG CC HSINDYSISP DGQFILLEYN YVKQWRHSYT ASYDIYDLNK RQLITEERIP NNTQWVTWSP CC VGHKLAYVWN NDIYVKIEPN LPSYRITWTG KEDIIYNGIT DWVYEEEVFS AYSALWWSPN CC GTFLAYAQFN DTEVPLIEYS FYSDESLQYP KTVRVPYPKA GAVNPTVKFF VVNTDSLSSV CC TNATSIQITA PASMLIGDHY LCDVTWATQE RISLQWLRRI QNYSVMDICD YDESSGRWNC CC LVARQHIEMS TTGWVGRFRP SEPHFTLDGN SFYKIISNEE GYRHICYFQI DKKDCTFITK CC GTWEVIGIEA LTSDYLYYIS NEYKGMPGGR NLYKIQLSDY TKVTCLSCEL NPERCQYYSV CC SFSKEAKYYQ LRCSGPGLPL YTLHSSVNDK GLRVLEDNSA LDKMLQNVQM PSKKLDFIIL CC NETKFWYQMI LPPHFDKSKK YPLLLDVYAG PCSQKADTVF RLNWATYLAS TENIIVASFD CC GRGSGYQGDK IMHAINRRLG TFEVEDQIEA ARQFSKMGFV DNKRIAIWGW SYGGYVTSMV CC LGSGSGVFKC GIAVAPVSRW EYYDSVYTER YMGLPTPEDN LDHYRNSTVM SRAENFKQVE CC YLLIHGTADD NVHFQQSAQI SKALVDVGVD FQAMWYTDED HGIASSTAHQ HIYTHMSHFI CC KQCFSLP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES ADPGGSHHHHHHSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ATOM -------------RKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ************************************* CC SEQRES LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ATOM LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ************************************************** CC SEQRES SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ATOM SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ************************************************** CC SEQRES EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ATOM EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ************************************************** CC SEQRES QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ATOM QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ************************************************** CC SEQRES SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ATOM SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ************************************************** CC SEQRES ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ATOM ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ************************************************** CC SEQRES NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ATOM NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ************************************************** CC SEQRES GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ATOM GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ************************************************** CC SEQRES LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ATOM LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ************************************************** CC SEQRES QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ATOM QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ************************************************** CC SEQRES SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ATOM SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ************************************************** CC SEQRES WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ATOM WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ************************************************** CC SEQRES EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ATOM EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ************************************************** CC SEQRES GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC ATOM GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC **************************************** SQ SEQUENCE 740 AA; MW; CN; ADPGGSHHHH HHSRKTYTLT DYLKNTYRLK LYSLRWISDH EYLYKQENNI LVFNAEYGNS SVFLENSTFD EFGHSINDYS ISPDGQFILL EYNYVKQWRH SYTASYDIYD LNKRQLITEE RIPNNTQWVT WSPVGHKLAY VWNNDIYVKI EPNLPSYRIT WTGKEDIIYN GITDWVYEEE VFSAYSALWW SPNGTFLAYA QFNDTEVPLI EYSFYSDESL QYPKTVRVPY PKAGAVNPTV KFFVVNTDSL SSVTNATSIQ ITAPASMLIG DHYLCDVTWA TQERISLQWL RRIQNYSVMD ICDYDESSGR WNCLVARQHI EMSTTGWVGR FRPSEPHFTL DGNSFYKIIS NEEGYRHICY FQIDKKDCTF ITKGTWEVIG IEALTSDYLY YISNEYKGMP GGRNLYKIQL SDYTKVTCLS CELNPERCQY YSVSFSKEAK YYQLRCSGPG LPLYTLHSSV NDKGLRVLED NSALDKMLQN VQMPSKKLDF IILNETKFWY QMILPPHFDK SKKYPLLLDV YAGPCSQKAD TVFRLNWATY LASTENIIVA SFDGRGSGYQ GDKIMHAINR RLGTFEVEDQ IEAARQFSKM GFVDNKRIAI WGWSYGGYVT SMVLGSGSGV FKCGIAVAPV SRWEYYDSVY TERYMGLPTP EDNLDHYRNS TVMSRAENFK QVEYLLIHGT ADDNVHFQQS AQISKALVDV GVDFQAMWYT DEDHGIASST AHQHIYTHMS HFIKQCFSLP // ID 3O95B STANDARD; PRT; 740 AA. DT CONVERTED FROM PDB (SEQRES) 3O95 DE Dipeptidyl peptidase 4 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.850 CC R-Factor 0.190 FT #SUB 208 234 PRO B 222 248 TYR A Protein S 8 FT #SUB 209 235 LEU B 222 248 TYR A Protein B 2 FT #SUB 210 236 ILE B 223 249 PRO A Protein S 1 FT #SUB 211 237 GLU B 213 239 SER A Protein B 1 FT #SUB 211 237 GLU B 225 251 THR A Protein S 7 FT #SUB 211 237 GLU B 227 253 ARG A Protein S 3 FT #SUB 212 238 TYR B 213 239 SER A Protein B 1 FT #SUB 213 239 SER B 211 237 GLU A Protein S 1 FT #SUB 213 239 SER B 212 238 TYR A Protein S 1 FT #SUB 215 241 TYR B 687 713 PHE A Protein S 3 FT #SUB 215 241 TYR B 688 714 GLN A Protein S 6 FT #SUB 215 241 TYR B 691 717 ALA A Protein S 3 FT #SUB 215 241 TYR B 692 718 GLN A Protein A 3 FT #SUB 216 242 SER B 692 718 GLN A Protein B 4 FT #SUB 216 242 SER B 695 721 LYS A Protein B 3 FT #SUB 217 243 ASP B 692 718 GLN A Protein B 2 FT #SUB 217 243 ASP B 695 721 LYS A Protein B 1 FT #SUB 218 244 GLU B 632 658 ARG A Protein A 5 FT #SUB 218 244 GLU B 635 661 TYR A Protein A 6 FT #SUB 218 244 GLU B 663 689 MET A Protein S 5 FT #SUB 218 244 GLU B 692 718 GLN A Protein A 8 FT #SUB 218 244 GLU B 695 721 LYS A Protein B 1 FT #SUB 220 246 LEU B 635 661 TYR A Protein B 1 FT #SUB 220 246 LEU B 688 714 GLN A Protein B 1 FT #SUB 221 247 GLN B 232 258 LYS A Protein A 7 FT #SUB 221 247 GLN B 233 259 ALA A Protein S 4 FT #SUB 221 247 GLN B 634 660 GLU A Protein S 4 FT #SUB 221 247 GLN B 635 661 TYR A Protein B 1 FT #SUB 221 247 GLN B 688 714 GLN A Protein B 4 FT #SUB 222 248 TYR B 208 234 PRO A Protein S 8 FT #SUB 222 248 TYR B 209 235 LEU A Protein S 2 FT #SUB 222 248 TYR B 230 256 TYR A Protein S 4 FT #SUB 222 248 TYR B 231 257 PRO A Protein S 2 FT #SUB 222 248 TYR B 232 258 LYS A Protein S 11 FT #SUB 222 248 TYR B 235 261 ALA A Protein S 1 FT #SUB 223 249 PRO B 210 236 ILE A Protein S 1 FT #SUB 223 249 PRO B 688 714 GLN A Protein A 8 FT #SUB 225 251 THR B 211 237 GLU A Protein S 6 FT #SUB 227 253 ARG B 211 237 GLU A Protein S 3 FT #SUB 227 253 ARG B 227 253 ARG A Protein S 5 FT #SUB 230 256 TYR B 222 248 TYR A Protein B 4 FT #SUB 231 257 PRO B 222 248 TYR A Protein B 2 FT #SUB 232 258 LYS B 221 247 GLN A Protein A 9 FT #SUB 232 258 LYS B 222 248 TYR A Protein A 16 FT #SUB 233 259 ALA B 221 247 GLN A Protein B 4 FT #SUB 235 261 ALA B 222 248 TYR A Protein S 1 FT #SUB 632 658 ARG B 218 244 GLU A Protein S 5 FT #SUB 634 660 GLU B 221 247 GLN A Protein B 4 FT #SUB 635 661 TYR B 218 244 GLU A Protein S 6 FT #SUB 635 661 TYR B 220 246 LEU A Protein S 1 FT #SUB 635 661 TYR B 221 247 GLN A Protein S 1 FT #SUB 661 687 THR B 218 244 GLU A Protein S 2 FT #SUB 663 689 MET B 218 244 GLU A Protein S 7 FT #SUB 676 702 LEU B 708 734 TRP A Protein S 1 FT #SUB 687 713 PHE B 215 241 TYR A Protein S 1 FT #SUB 687 713 PHE B 708 734 TRP A Protein S 6 FT #SUB 688 714 GLN B 215 241 TYR A Protein A 4 FT #SUB 688 714 GLN B 220 246 LEU A Protein S 1 FT #SUB 688 714 GLN B 221 247 GLN A Protein S 4 FT #SUB 688 714 GLN B 223 249 PRO A Protein S 6 FT #SUB 690 716 SER B 708 734 TRP A Protein B 2 FT #SUB 691 717 ALA B 215 241 TYR A Protein S 2 FT #SUB 691 717 ALA B 708 734 TRP A Protein B 1 FT #SUB 691 717 ALA B 710 736 THR A Protein A 8 FT #SUB 692 718 GLN B 215 241 TYR A Protein S 3 FT #SUB 692 718 GLN B 216 242 SER A Protein S 4 FT #SUB 692 718 GLN B 217 243 ASP A Protein S 2 FT #SUB 692 718 GLN B 218 244 GLU A Protein S 6 FT #SUB 694 720 SER B 708 734 TRP A Protein S 5 FT #SUB 694 720 SER B 710 736 THR A Protein S 2 FT #SUB 695 721 LYS B 216 242 SER A Protein S 2 FT #SUB 695 721 LYS B 710 736 THR A Protein S 4 FT #SUB 695 721 LYS B 711 737 ASP A Protein S 1 FT #SUB 698 724 VAL B 709 735 TYR A Protein S 2 FT #SUB 698 724 VAL B 720 746 THR A Protein A 3 FT #SUB 698 724 VAL B 721 747 ALA A Protein S 2 FT #SUB 698 724 VAL B 724 750 HIS A Protein A 4 FT #SUB 699 725 ASP B 720 746 THR A Protein A 2 FT #SUB 702 728 VAL B 724 750 HIS A Protein B 3 FT #SUB 703 729 ASP B 724 750 HIS A Protein A 2 FT #SUB 703 729 ASP B 728 754 HIS A Protein S 7 FT #SUB 703 729 ASP B 731 757 HIS A Protein S 3 FT #SUB 704 730 PHE B 707 733 MET A Protein B 1 FT #SUB 704 730 PHE B 724 750 HIS A Protein S 4 FT #SUB 704 730 PHE B 728 754 HIS A Protein B 2 FT #SUB 705 731 GLN B 705 731 GLN A Protein S 1 FT #SUB 706 732 ALA B 706 732 ALA A Protein A 7 FT #SUB 706 732 ALA B 707 733 MET A Protein S 1 FT #SUB 707 733 MET B 704 730 PHE A Protein S 1 FT #SUB 707 733 MET B 706 732 ALA A Protein S 1 FT #SUB 707 733 MET B 708 734 TRP A Protein B 3 FT #SUB 708 734 TRP B 687 713 PHE A Protein S 2 FT #SUB 708 734 TRP B 694 720 SER A Protein S 6 FT #SUB 708 734 TRP B 706 732 ALA A Protein S 1 FT #SUB 708 734 TRP B 707 733 MET A Protein S 3 FT #SUB 708 734 TRP B 708 734 TRP A Protein A 7 FT #SUB 709 735 TYR B 698 724 VAL A Protein S 2 FT #SUB 710 736 THR B 691 717 ALA A Protein S 8 FT #SUB 710 736 THR B 694 720 SER A Protein S 2 FT #SUB 710 736 THR B 695 721 LYS A Protein S 2 FT #SUB 711 737 ASP B 695 721 LYS A Protein S 1 FT #SUB 720 746 THR B 698 724 VAL A Protein A 3 FT #SUB 720 746 THR B 699 725 ASP A Protein S 7 FT #SUB 721 747 ALA B 698 724 VAL A Protein B 2 FT #SUB 724 750 HIS B 698 724 VAL A Protein S 2 FT #SUB 724 750 HIS B 702 728 VAL A Protein S 5 FT #SUB 724 750 HIS B 703 729 ASP A Protein S 3 FT #SUB 724 750 HIS B 704 730 PHE A Protein S 4 FT #SUB 728 754 HIS B 703 729 ASP A Protein S 6 FT #SUB 728 754 HIS B 704 730 PHE A Protein S 2 FT #SUB 731 757 HIS B 703 729 ASP A Protein S 3 FT #HET 57 83 TYR B 10 2 NAG I S 1 FT #HET 61 87 SER B 9 1 NAG I S 2 FT #HET 99 125 ARG B 24 1 01T B S 13 FT #HET 121 147 ARG B 21 1501 NAG B S 2 FT #HET 122 148 ILE B 21 1501 NAG B B 1 FT #HET 161 187 TRP B 22 2811 NAG B S 8 FT #HET 168 194 ILE B 11 1 NAG J S 2 FT #HET 179 205 GLU B 24 1 01T B A 8 FT #HET 180 206 GLU B 24 1 01T B S 6 FT #HET 183 209 SER B 24 1 01T B S 1 FT #HET 205 231 THR B 11 1 NAG J S 4 FT #HET 206 232 GLU B 11 1 NAG J S 1 FT #HET 206 232 GLU B 12 2 NAG J S 2 FT #HET 293 319 ILE B 23 3211 NAG B S 1 FT #HET 322 348 MET B 23 3211 NAG B S 1 FT #HET 323 349 SER B 23 3211 NAG B B 1 FT #HET 331 357 PHE B 24 1 01T B S 1 FT #HET 521 547 TYR B 24 1 01T B S 4 FT #HET 604 630 SER B 24 1 01T B S 6 FT #HET 605 631 TYR B 24 1 01T B B 1 FT #HET 630 656 VAL B 24 1 01T B S 1 FT #HET 636 662 TYR B 24 1 01T B S 11 FT #HET 640 666 TYR B 24 1 01T B S 9 FT #HET 684 710 ASN B 24 1 01T B S 1 FT #HET 714 740 HIS B 24 1 01T B S 4 FT #MOD 59 85 ASN B 9 1 NAG I S FT #MOD 124 150 ASN B 21 1501 NAG B S FT #MOD 203 229 ASN B 11 1 NAG J S FT #MOD 255 281 ASN B 22 2811 NAG B S FT #MOD 295 321 ASN B 23 3211 NAG B S FT DISORDER 1 7 CC SEQUENCE 733 AA (ATOM); CC HHHHHSRKTY TLTDYLKNTY RLKLYSLRWI SDHEYLYKQE NNILVFNAEY GNSSVFLENS CC TFDEFGHSIN DYSISPDGQF ILLEYNYVKQ WRHSYTASYD IYDLNKRQLI TEERIPNNTQ CC WVTWSPVGHK LAYVWNNDIY VKIEPNLPSY RITWTGKEDI IYNGITDWVY EEEVFSAYSA CC LWWSPNGTFL AYAQFNDTEV PLIEYSFYSD ESLQYPKTVR VPYPKAGAVN PTVKFFVVNT CC DSLSSVTNAT SIQITAPASM LIGDHYLCDV TWATQERISL QWLRRIQNYS VMDICDYDES CC SGRWNCLVAR QHIEMSTTGW VGRFRPSEPH FTLDGNSFYK IISNEEGYRH ICYFQIDKKD CC CTFITKGTWE VIGIEALTSD YLYYISNEYK GMPGGRNLYK IQLSDYTKVT CLSCELNPER CC CQYYSVSFSK EAKYYQLRCS GPGLPLYTLH SSVNDKGLRV LEDNSALDKM LQNVQMPSKK CC LDFIILNETK FWYQMILPPH FDKSKKYPLL LDVYAGPCSQ KADTVFRLNW ATYLASTENI CC IVASFDGRGS GYQGDKIMHA INRRLGTFEV EDQIEAARQF SKMGFVDNKR IAIWGWSYGG CC YVTSMVLGSG SGVFKCGIAV APVSRWEYYD SVYTERYMGL PTPEDNLDHY RNSTVMSRAE CC NFKQVEYLLI HGTADDNVHF QQSAQISKAL VDVGVDFQAM WYTDEDHGIA SSTAHQHIYT CC HMSHFIKQCF SLP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES ADPGGSHHHHHHSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ATOM -------HHHHHSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ******************************************* CC SEQRES LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ATOM LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ************************************************** CC SEQRES SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ATOM SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ************************************************** CC SEQRES EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ATOM EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ************************************************** CC SEQRES QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ATOM QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ************************************************** CC SEQRES SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ATOM SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ************************************************** CC SEQRES ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ATOM ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ************************************************** CC SEQRES NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ATOM NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ************************************************** CC SEQRES GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ATOM GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ************************************************** CC SEQRES LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ATOM LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ************************************************** CC SEQRES QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ATOM QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ************************************************** CC SEQRES SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ATOM SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ************************************************** CC SEQRES WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ATOM WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ************************************************** CC SEQRES EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ATOM EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ************************************************** CC SEQRES GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC ATOM GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC **************************************** SQ SEQUENCE 740 AA; MW; CN; ADPGGSHHHH HHSRKTYTLT DYLKNTYRLK LYSLRWISDH EYLYKQENNI LVFNAEYGNS SVFLENSTFD EFGHSINDYS ISPDGQFILL EYNYVKQWRH SYTASYDIYD LNKRQLITEE RIPNNTQWVT WSPVGHKLAY VWNNDIYVKI EPNLPSYRIT WTGKEDIIYN GITDWVYEEE VFSAYSALWW SPNGTFLAYA QFNDTEVPLI EYSFYSDESL QYPKTVRVPY PKAGAVNPTV KFFVVNTDSL SSVTNATSIQ ITAPASMLIG DHYLCDVTWA TQERISLQWL RRIQNYSVMD ICDYDESSGR WNCLVARQHI EMSTTGWVGR FRPSEPHFTL DGNSFYKIIS NEEGYRHICY FQIDKKDCTF ITKGTWEVIG IEALTSDYLY YISNEYKGMP GGRNLYKIQL SDYTKVTCLS CELNPERCQY YSVSFSKEAK YYQLRCSGPG LPLYTLHSSV NDKGLRVLED NSALDKMLQN VQMPSKKLDF IILNETKFWY QMILPPHFDK SKKYPLLLDV YAGPCSQKAD TVFRLNWATY LASTENIIVA SFDGRGSGYQ GDKIMHAINR RLGTFEVEDQ IEAARQFSKM GFVDNKRIAI WGWSYGGYVT SMVLGSGSGV FKCGIAVAPV SRWEYYDSVY TERYMGLPTP EDNLDHYRNS TVMSRAENFK QVEYLLIHGT ADDNVHFQQS AQISKALVDV GVDFQAMWYT DEDHGIASST AHQHIYTHMS HFIKQCFSLP // ID 3O95C STANDARD; PRT; 740 AA. DT CONVERTED FROM PDB (SEQRES) 3O95 DE Dipeptidyl peptidase 4 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.850 CC R-Factor 0.190 FT #SUB 208 234 PRO C 222 248 TYR D Protein S 6 FT #SUB 209 235 LEU C 222 248 TYR D Protein B 3 FT #SUB 210 236 ILE C 223 249 PRO D Protein S 2 FT #SUB 211 237 GLU C 213 239 SER D Protein B 1 FT #SUB 211 237 GLU C 225 251 THR D Protein S 6 FT #SUB 211 237 GLU C 227 253 ARG D Protein S 3 FT #SUB 212 238 TYR C 213 239 SER D Protein B 1 FT #SUB 215 241 TYR C 687 713 PHE D Protein S 1 FT #SUB 215 241 TYR C 688 714 GLN D Protein S 3 FT #SUB 215 241 TYR C 691 717 ALA D Protein S 2 FT #SUB 215 241 TYR C 692 718 GLN D Protein A 3 FT #SUB 216 242 SER C 692 718 GLN D Protein B 3 FT #SUB 216 242 SER C 695 721 LYS D Protein B 3 FT #SUB 217 243 ASP C 692 718 GLN D Protein B 2 FT #SUB 217 243 ASP C 695 721 LYS D Protein B 1 FT #SUB 218 244 GLU C 632 658 ARG D Protein A 6 FT #SUB 218 244 GLU C 635 661 TYR D Protein A 6 FT #SUB 218 244 GLU C 663 689 MET D Protein S 6 FT #SUB 218 244 GLU C 692 718 GLN D Protein A 7 FT #SUB 220 246 LEU C 635 661 TYR D Protein B 1 FT #SUB 220 246 LEU C 688 714 GLN D Protein B 1 FT #SUB 221 247 GLN C 232 258 LYS D Protein A 6 FT #SUB 221 247 GLN C 233 259 ALA D Protein S 4 FT #SUB 221 247 GLN C 634 660 GLU D Protein S 6 FT #SUB 221 247 GLN C 635 661 TYR D Protein B 1 FT #SUB 221 247 GLN C 688 714 GLN D Protein B 4 FT #SUB 222 248 TYR C 208 234 PRO D Protein S 8 FT #SUB 222 248 TYR C 209 235 LEU D Protein S 1 FT #SUB 222 248 TYR C 230 256 TYR D Protein S 4 FT #SUB 222 248 TYR C 231 257 PRO D Protein S 3 FT #SUB 222 248 TYR C 232 258 LYS D Protein S 16 FT #SUB 222 248 TYR C 235 261 ALA D Protein S 1 FT #SUB 223 249 PRO C 210 236 ILE D Protein S 1 FT #SUB 223 249 PRO C 688 714 GLN D Protein A 7 FT #SUB 225 251 THR C 211 237 GLU D Protein S 5 FT #SUB 227 253 ARG C 211 237 GLU D Protein S 3 FT #SUB 227 253 ARG C 227 253 ARG D Protein S 5 FT #SUB 230 256 TYR C 222 248 TYR D Protein B 4 FT #SUB 231 257 PRO C 222 248 TYR D Protein B 2 FT #SUB 232 258 LYS C 221 247 GLN D Protein A 6 FT #SUB 232 258 LYS C 222 248 TYR D Protein A 14 FT #SUB 233 259 ALA C 221 247 GLN D Protein B 4 FT #SUB 235 261 ALA C 222 248 TYR D Protein S 1 FT #SUB 632 658 ARG C 218 244 GLU D Protein S 6 FT #SUB 634 660 GLU C 221 247 GLN D Protein A 5 FT #SUB 635 661 TYR C 218 244 GLU D Protein S 6 FT #SUB 635 661 TYR C 220 246 LEU D Protein S 1 FT #SUB 635 661 TYR C 221 247 GLN D Protein S 1 FT #SUB 663 689 MET C 218 244 GLU D Protein S 2 FT #SUB 676 702 LEU C 708 734 TRP D Protein S 2 FT #SUB 687 713 PHE C 215 241 TYR D Protein S 3 FT #SUB 687 713 PHE C 708 734 TRP D Protein S 8 FT #SUB 688 714 GLN C 215 241 TYR D Protein A 5 FT #SUB 688 714 GLN C 220 246 LEU D Protein S 1 FT #SUB 688 714 GLN C 221 247 GLN D Protein S 4 FT #SUB 688 714 GLN C 223 249 PRO D Protein S 7 FT #SUB 690 716 SER C 708 734 TRP D Protein B 1 FT #SUB 691 717 ALA C 215 241 TYR D Protein S 3 FT #SUB 691 717 ALA C 710 736 THR D Protein A 7 FT #SUB 692 718 GLN C 215 241 TYR D Protein S 3 FT #SUB 692 718 GLN C 216 242 SER D Protein S 4 FT #SUB 692 718 GLN C 217 243 ASP D Protein S 2 FT #SUB 692 718 GLN C 218 244 GLU D Protein S 6 FT #SUB 694 720 SER C 708 734 TRP D Protein S 6 FT #SUB 694 720 SER C 710 736 THR D Protein S 1 FT #SUB 695 721 LYS C 216 242 SER D Protein S 2 FT #SUB 695 721 LYS C 710 736 THR D Protein S 2 FT #SUB 695 721 LYS C 711 737 ASP D Protein S 1 FT #SUB 698 724 VAL C 709 735 TYR D Protein S 1 FT #SUB 698 724 VAL C 720 746 THR D Protein A 5 FT #SUB 698 724 VAL C 721 747 ALA D Protein S 2 FT #SUB 698 724 VAL C 724 750 HIS D Protein A 4 FT #SUB 699 725 ASP C 720 746 THR D Protein A 7 FT #SUB 702 728 VAL C 724 750 HIS D Protein B 4 FT #SUB 703 729 ASP C 724 750 HIS D Protein B 1 FT #SUB 703 729 ASP C 728 754 HIS D Protein S 6 FT #SUB 703 729 ASP C 731 757 HIS D Protein S 3 FT #SUB 704 730 PHE C 707 733 MET D Protein B 1 FT #SUB 704 730 PHE C 724 750 HIS D Protein S 4 FT #SUB 704 730 PHE C 728 754 HIS D Protein B 3 FT #SUB 705 731 GLN C 705 731 GLN D Protein S 3 FT #SUB 705 731 GLN C 728 754 HIS D Protein S 1 FT #SUB 706 732 ALA C 706 732 ALA D Protein B 5 FT #SUB 706 732 ALA C 707 733 MET D Protein S 1 FT #SUB 706 732 ALA C 708 734 TRP D Protein S 1 FT #SUB 707 733 MET C 704 730 PHE D Protein S 4 FT #SUB 707 733 MET C 706 732 ALA D Protein S 2 FT #SUB 707 733 MET C 708 734 TRP D Protein B 3 FT #SUB 708 734 TRP C 676 702 LEU D Protein S 2 FT #SUB 708 734 TRP C 687 713 PHE D Protein S 4 FT #SUB 708 734 TRP C 690 716 SER D Protein S 2 FT #SUB 708 734 TRP C 691 717 ALA D Protein S 1 FT #SUB 708 734 TRP C 694 720 SER D Protein S 7 FT #SUB 708 734 TRP C 706 732 ALA D Protein S 3 FT #SUB 708 734 TRP C 707 733 MET D Protein S 3 FT #SUB 708 734 TRP C 708 734 TRP D Protein A 7 FT #SUB 709 735 TYR C 698 724 VAL D Protein S 2 FT #SUB 710 736 THR C 691 717 ALA D Protein S 8 FT #SUB 710 736 THR C 694 720 SER D Protein S 2 FT #SUB 710 736 THR C 695 721 LYS D Protein S 2 FT #SUB 720 746 THR C 698 724 VAL D Protein A 5 FT #SUB 720 746 THR C 699 725 ASP D Protein S 5 FT #SUB 721 747 ALA C 698 724 VAL D Protein B 2 FT #SUB 724 750 HIS C 698 724 VAL D Protein S 7 FT #SUB 724 750 HIS C 702 728 VAL D Protein S 3 FT #SUB 724 750 HIS C 703 729 ASP D Protein S 2 FT #SUB 724 750 HIS C 704 730 PHE D Protein S 3 FT #SUB 728 754 HIS C 703 729 ASP D Protein S 5 FT #SUB 728 754 HIS C 704 730 PHE D Protein S 2 FT #SUB 731 757 HIS C 703 729 ASP D Protein S 3 FT #HET 99 125 ARG C 28 1 01T C S 11 FT #HET 121 147 ARG C 25 1501 NAG C S 4 FT #HET 122 148 ILE C 25 1501 NAG C B 1 FT #HET 161 187 TRP C 26 2811 NAG C S 2 FT #HET 168 194 ILE C 13 1 NAG K S 2 FT #HET 179 205 GLU C 28 1 01T C A 7 FT #HET 180 206 GLU C 28 1 01T C A 7 FT #HET 183 209 SER C 28 1 01T C S 1 FT #HET 205 231 THR C 13 1 NAG K S 7 FT #HET 205 231 THR C 14 2 NAG K S 2 FT #HET 206 232 GLU C 13 1 NAG K S 4 FT #HET 241 267 LYS C 13 1 NAG K S 1 FT #HET 293 319 ILE C 27 3211 NAG C S 2 FT #HET 331 357 PHE C 28 1 01T C S 2 FT #HET 521 547 TYR C 28 1 01T C S 2 FT #HET 604 630 SER C 28 1 01T C S 6 FT #HET 605 631 TYR C 28 1 01T C B 1 FT #HET 630 656 VAL C 28 1 01T C S 1 FT #HET 636 662 TYR C 28 1 01T C S 10 FT #HET 640 666 TYR C 28 1 01T C S 9 FT #HET 685 711 VAL C 28 1 01T C S 1 FT #HET 714 740 HIS C 28 1 01T C S 3 FT #MOD 124 150 ASN C 25 1501 NAG C S FT #MOD 203 229 ASN C 13 1 NAG K S FT #MOD 255 281 ASN C 26 2811 NAG C S FT #MOD 295 321 ASN C 27 3211 NAG C S FT DISORDER 1 14 CC SEQUENCE 726 AA (ATOM); CC KTYTLTDYLK NTYRLKLYSL RWISDHEYLY KQENNILVFN AEYGNSSVFL ENSTFDEFGH CC SINDYSISPD GQFILLEYNY VKQWRHSYTA SYDIYDLNKR QLITEERIPN NTQWVTWSPV CC GHKLAYVWNN DIYVKIEPNL PSYRITWTGK EDIIYNGITD WVYEEEVFSA YSALWWSPNG CC TFLAYAQFND TEVPLIEYSF YSDESLQYPK TVRVPYPKAG AVNPTVKFFV VNTDSLSSVT CC NATSIQITAP ASMLIGDHYL CDVTWATQER ISLQWLRRIQ NYSVMDICDY DESSGRWNCL CC VARQHIEMST TGWVGRFRPS EPHFTLDGNS FYKIISNEEG YRHICYFQID KKDCTFITKG CC TWEVIGIEAL TSDYLYYISN EYKGMPGGRN LYKIQLSDYT KVTCLSCELN PERCQYYSVS CC FSKEAKYYQL RCSGPGLPLY TLHSSVNDKG LRVLEDNSAL DKMLQNVQMP SKKLDFIILN CC ETKFWYQMIL PPHFDKSKKY PLLLDVYAGP CSQKADTVFR LNWATYLAST ENIIVASFDG CC RGSGYQGDKI MHAINRRLGT FEVEDQIEAA RQFSKMGFVD NKRIAIWGWS YGGYVTSMVL CC GSGSGVFKCG IAVAPVSRWE YYDSVYTERY MGLPTPEDNL DHYRNSTVMS RAENFKQVEY CC LLIHGTADDN VHFQQSAQIS KALVDVGVDF QAMWYTDEDH GIASSTAHQH IYTHMSHFIK CC QCFSLP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES ADPGGSHHHHHHSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ATOM --------------KTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ************************************ CC SEQRES LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ATOM LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ************************************************** CC SEQRES SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ATOM SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ************************************************** CC SEQRES EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ATOM EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ************************************************** CC SEQRES QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ATOM QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ************************************************** CC SEQRES SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ATOM SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ************************************************** CC SEQRES ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ATOM ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ************************************************** CC SEQRES NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ATOM NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ************************************************** CC SEQRES GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ATOM GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ************************************************** CC SEQRES LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ATOM LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ************************************************** CC SEQRES QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ATOM QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ************************************************** CC SEQRES SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ATOM SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ************************************************** CC SEQRES WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ATOM WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ************************************************** CC SEQRES EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ATOM EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ************************************************** CC SEQRES GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC ATOM GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC **************************************** SQ SEQUENCE 740 AA; MW; CN; ADPGGSHHHH HHSRKTYTLT DYLKNTYRLK LYSLRWISDH EYLYKQENNI LVFNAEYGNS SVFLENSTFD EFGHSINDYS ISPDGQFILL EYNYVKQWRH SYTASYDIYD LNKRQLITEE RIPNNTQWVT WSPVGHKLAY VWNNDIYVKI EPNLPSYRIT WTGKEDIIYN GITDWVYEEE VFSAYSALWW SPNGTFLAYA QFNDTEVPLI EYSFYSDESL QYPKTVRVPY PKAGAVNPTV KFFVVNTDSL SSVTNATSIQ ITAPASMLIG DHYLCDVTWA TQERISLQWL RRIQNYSVMD ICDYDESSGR WNCLVARQHI EMSTTGWVGR FRPSEPHFTL DGNSFYKIIS NEEGYRHICY FQIDKKDCTF ITKGTWEVIG IEALTSDYLY YISNEYKGMP GGRNLYKIQL SDYTKVTCLS CELNPERCQY YSVSFSKEAK YYQLRCSGPG LPLYTLHSSV NDKGLRVLED NSALDKMLQN VQMPSKKLDF IILNETKFWY QMILPPHFDK SKKYPLLLDV YAGPCSQKAD TVFRLNWATY LASTENIIVA SFDGRGSGYQ GDKIMHAINR RLGTFEVEDQ IEAARQFSKM GFVDNKRIAI WGWSYGGYVT SMVLGSGSGV FKCGIAVAPV SRWEYYDSVY TERYMGLPTP EDNLDHYRNS TVMSRAENFK QVEYLLIHGT ADDNVHFQQS AQISKALVDV GVDFQAMWYT DEDHGIASST AHQHIYTHMS HFIKQCFSLP // ID 3O95D STANDARD; PRT; 740 AA. DT CONVERTED FROM PDB (SEQRES) 3O95 DE Dipeptidyl peptidase 4 OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.850 CC R-Factor 0.190 FT #SUB 14 40 ARG D 25 51 ASN A Protein S 2 FT #SUB 14 40 ARG D 28 54 ARG A Protein S 1 FT #SUB 509 535 ASP D 15 41 LYS A Protein S 2 FT #SUB 512 538 LYS D 15 41 LYS A Protein S 1 FT #SUB 208 234 PRO D 222 248 TYR C Protein S 8 FT #SUB 209 235 LEU D 222 248 TYR C Protein B 1 FT #SUB 210 236 ILE D 223 249 PRO C Protein S 1 FT #SUB 211 237 GLU D 225 251 THR C Protein S 5 FT #SUB 211 237 GLU D 227 253 ARG C Protein S 3 FT #SUB 213 239 SER D 211 237 GLU C Protein S 1 FT #SUB 213 239 SER D 212 238 TYR C Protein S 1 FT #SUB 215 241 TYR D 687 713 PHE C Protein S 3 FT #SUB 215 241 TYR D 688 714 GLN C Protein S 5 FT #SUB 215 241 TYR D 691 717 ALA C Protein S 3 FT #SUB 215 241 TYR D 692 718 GLN C Protein A 3 FT #SUB 216 242 SER D 692 718 GLN C Protein B 4 FT #SUB 216 242 SER D 695 721 LYS C Protein B 2 FT #SUB 217 243 ASP D 692 718 GLN C Protein B 2 FT #SUB 218 244 GLU D 632 658 ARG C Protein A 6 FT #SUB 218 244 GLU D 635 661 TYR C Protein A 6 FT #SUB 218 244 GLU D 663 689 MET C Protein S 2 FT #SUB 218 244 GLU D 692 718 GLN C Protein A 6 FT #SUB 220 246 LEU D 635 661 TYR C Protein B 1 FT #SUB 220 246 LEU D 688 714 GLN C Protein B 1 FT #SUB 221 247 GLN D 232 258 LYS C Protein A 6 FT #SUB 221 247 GLN D 233 259 ALA C Protein S 4 FT #SUB 221 247 GLN D 634 660 GLU C Protein S 5 FT #SUB 221 247 GLN D 635 661 TYR C Protein B 1 FT #SUB 221 247 GLN D 688 714 GLN C Protein B 4 FT #SUB 222 248 TYR D 208 234 PRO C Protein S 6 FT #SUB 222 248 TYR D 209 235 LEU C Protein S 3 FT #SUB 222 248 TYR D 230 256 TYR C Protein S 4 FT #SUB 222 248 TYR D 231 257 PRO C Protein S 2 FT #SUB 222 248 TYR D 232 258 LYS C Protein S 14 FT #SUB 222 248 TYR D 235 261 ALA C Protein S 1 FT #SUB 223 249 PRO D 210 236 ILE C Protein S 2 FT #SUB 223 249 PRO D 688 714 GLN C Protein S 7 FT #SUB 225 251 THR D 211 237 GLU C Protein A 6 FT #SUB 227 253 ARG D 211 237 GLU C Protein S 3 FT #SUB 227 253 ARG D 227 253 ARG C Protein S 5 FT #SUB 230 256 TYR D 222 248 TYR C Protein B 4 FT #SUB 231 257 PRO D 222 248 TYR C Protein B 3 FT #SUB 232 258 LYS D 221 247 GLN C Protein S 6 FT #SUB 232 258 LYS D 222 248 TYR C Protein A 16 FT #SUB 233 259 ALA D 221 247 GLN C Protein B 4 FT #SUB 235 261 ALA D 222 248 TYR C Protein S 1 FT #SUB 632 658 ARG D 218 244 GLU C Protein S 6 FT #SUB 634 660 GLU D 221 247 GLN C Protein A 6 FT #SUB 635 661 TYR D 218 244 GLU C Protein S 6 FT #SUB 635 661 TYR D 220 246 LEU C Protein S 1 FT #SUB 635 661 TYR D 221 247 GLN C Protein S 1 FT #SUB 663 689 MET D 218 244 GLU C Protein S 6 FT #SUB 676 702 LEU D 708 734 TRP C Protein S 2 FT #SUB 687 713 PHE D 215 241 TYR C Protein S 1 FT #SUB 687 713 PHE D 708 734 TRP C Protein S 4 FT #SUB 688 714 GLN D 215 241 TYR C Protein A 3 FT #SUB 688 714 GLN D 220 246 LEU C Protein S 1 FT #SUB 688 714 GLN D 221 247 GLN C Protein S 4 FT #SUB 688 714 GLN D 223 249 PRO C Protein S 7 FT #SUB 690 716 SER D 708 734 TRP C Protein B 2 FT #SUB 691 717 ALA D 215 241 TYR C Protein S 2 FT #SUB 691 717 ALA D 708 734 TRP C Protein B 1 FT #SUB 691 717 ALA D 710 736 THR C Protein A 8 FT #SUB 692 718 GLN D 215 241 TYR C Protein S 3 FT #SUB 692 718 GLN D 216 242 SER C Protein S 3 FT #SUB 692 718 GLN D 217 243 ASP C Protein S 2 FT #SUB 692 718 GLN D 218 244 GLU C Protein S 7 FT #SUB 694 720 SER D 708 734 TRP C Protein S 7 FT #SUB 694 720 SER D 710 736 THR C Protein S 2 FT #SUB 695 721 LYS D 216 242 SER C Protein S 3 FT #SUB 695 721 LYS D 217 243 ASP C Protein S 1 FT #SUB 695 721 LYS D 710 736 THR C Protein S 2 FT #SUB 698 724 VAL D 709 735 TYR C Protein S 2 FT #SUB 698 724 VAL D 720 746 THR C Protein A 5 FT #SUB 698 724 VAL D 721 747 ALA C Protein S 2 FT #SUB 698 724 VAL D 724 750 HIS C Protein A 7 FT #SUB 699 725 ASP D 720 746 THR C Protein A 5 FT #SUB 702 728 VAL D 724 750 HIS C Protein B 3 FT #SUB 703 729 ASP D 724 750 HIS C Protein S 2 FT #SUB 703 729 ASP D 728 754 HIS C Protein S 5 FT #SUB 703 729 ASP D 731 757 HIS C Protein S 3 FT #SUB 704 730 PHE D 707 733 MET C Protein A 4 FT #SUB 704 730 PHE D 724 750 HIS C Protein S 3 FT #SUB 704 730 PHE D 728 754 HIS C Protein B 2 FT #SUB 705 731 GLN D 705 731 GLN C Protein S 3 FT #SUB 706 732 ALA D 706 732 ALA C Protein B 5 FT #SUB 706 732 ALA D 707 733 MET C Protein A 2 FT #SUB 706 732 ALA D 708 734 TRP C Protein S 3 FT #SUB 707 733 MET D 704 730 PHE C Protein S 1 FT #SUB 707 733 MET D 706 732 ALA C Protein S 1 FT #SUB 707 733 MET D 708 734 TRP C Protein B 3 FT #SUB 708 734 TRP D 676 702 LEU C Protein S 2 FT #SUB 708 734 TRP D 687 713 PHE C Protein S 8 FT #SUB 708 734 TRP D 690 716 SER C Protein S 1 FT #SUB 708 734 TRP D 694 720 SER C Protein S 6 FT #SUB 708 734 TRP D 706 732 ALA C Protein S 1 FT #SUB 708 734 TRP D 707 733 MET C Protein S 3 FT #SUB 708 734 TRP D 708 734 TRP C Protein A 7 FT #SUB 709 735 TYR D 698 724 VAL C Protein S 1 FT #SUB 710 736 THR D 691 717 ALA C Protein S 7 FT #SUB 710 736 THR D 694 720 SER C Protein S 1 FT #SUB 710 736 THR D 695 721 LYS C Protein S 2 FT #SUB 711 737 ASP D 695 721 LYS C Protein S 1 FT #SUB 720 746 THR D 698 724 VAL C Protein A 5 FT #SUB 720 746 THR D 699 725 ASP C Protein S 7 FT #SUB 721 747 ALA D 698 724 VAL C Protein B 2 FT #SUB 724 750 HIS D 698 724 VAL C Protein S 4 FT #SUB 724 750 HIS D 702 728 VAL C Protein S 4 FT #SUB 724 750 HIS D 703 729 ASP C Protein S 1 FT #SUB 724 750 HIS D 704 730 PHE C Protein S 4 FT #SUB 728 754 HIS D 703 729 ASP C Protein S 6 FT #SUB 728 754 HIS D 704 730 PHE C Protein S 3 FT #SUB 728 754 HIS D 705 731 GLN C Protein S 1 FT #SUB 731 757 HIS D 703 729 ASP C Protein S 3 FT #HET 99 125 ARG D 33 1 01T D S 16 FT #HET 161 187 TRP D 31 2811 NAG D S 15 FT #HET 168 194 ILE D 16 1 NAG L S 1 FT #HET 179 205 GLU D 33 1 01T D A 10 FT #HET 180 206 GLU D 33 1 01T D S 6 FT #HET 183 209 SER D 33 1 01T D S 1 FT #HET 195 221 THR D 30 2191 NAG D S 3 FT #HET 201 227 GLN D 16 1 NAG L S 1 FT #HET 205 231 THR D 16 1 NAG L S 7 FT #HET 206 232 GLU D 16 1 NAG L S 2 FT #HET 206 232 GLU D 17 2 NAG L S 1 FT #HET 241 267 LYS D 16 1 NAG L S 1 FT #HET 282 308 GLN D 30 2191 NAG D S 1 FT #HET 283 309 GLU D 30 2191 NAG D S 5 FT #HET 331 357 PHE D 33 1 01T D S 2 FT #HET 493 519 LEU D 32 5201 NAG D B 1 FT #HET 498 524 PHE D 32 5201 NAG D S 2 FT #HET 521 547 TYR D 33 1 01T D S 4 FT #HET 555 581 ARG D 32 5201 NAG D S 6 FT #HET 604 630 SER D 33 1 01T D S 7 FT #HET 605 631 TYR D 33 1 01T D B 1 FT #HET 630 656 VAL D 33 1 01T D S 1 FT #HET 636 662 TYR D 33 1 01T D S 9 FT #HET 640 666 TYR D 33 1 01T D S 8 FT #HET 714 740 HIS D 33 1 01T D S 2 FT #MOD 124 150 ASN D 29 1501 NAG D S FT #MOD 193 219 ASN D 30 2191 NAG D S FT #MOD 203 229 ASN D 16 1 NAG L S FT #MOD 255 281 ASN D 31 2811 NAG D S FT #MOD 494 520 ASN D 32 5201 NAG D S FT DISORDER 1 13 CC SEQUENCE 727 AA (ATOM); CC RKTYTLTDYL KNTYRLKLYS LRWISDHEYL YKQENNILVF NAEYGNSSVF LENSTFDEFG CC HSINDYSISP DGQFILLEYN YVKQWRHSYT ASYDIYDLNK RQLITEERIP NNTQWVTWSP CC VGHKLAYVWN NDIYVKIEPN LPSYRITWTG KEDIIYNGIT DWVYEEEVFS AYSALWWSPN CC GTFLAYAQFN DTEVPLIEYS FYSDESLQYP KTVRVPYPKA GAVNPTVKFF VVNTDSLSSV CC TNATSIQITA PASMLIGDHY LCDVTWATQE RISLQWLRRI QNYSVMDICD YDESSGRWNC CC LVARQHIEMS TTGWVGRFRP SEPHFTLDGN SFYKIISNEE GYRHICYFQI DKKDCTFITK CC GTWEVIGIEA LTSDYLYYIS NEYKGMPGGR NLYKIQLSDY TKVTCLSCEL NPERCQYYSV CC SFSKEAKYYQ LRCSGPGLPL YTLHSSVNDK GLRVLEDNSA LDKMLQNVQM PSKKLDFIIL CC NETKFWYQMI LPPHFDKSKK YPLLLDVYAG PCSQKADTVF RLNWATYLAS TENIIVASFD CC GRGSGYQGDK IMHAINRRLG TFEVEDQIEA ARQFSKMGFV DNKRIAIWGW SYGGYVTSMV CC LGSGSGVFKC GIAVAPVSRW EYYDSVYTER YMGLPTPEDN LDHYRNSTVM SRAENFKQVE CC YLLIHGTADD NVHFQQSAQI SKALVDVGVD FQAMWYTDED HGIASSTAHQ HIYTHMSHFI CC KQCFSLP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES ADPGGSHHHHHHSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ATOM -------------RKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNI CC ************************************* CC SEQRES LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ATOM LVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRH CC ************************************************** CC SEQRES SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ATOM SYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKI CC ************************************************** CC SEQRES EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ATOM EPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYA CC ************************************************** CC SEQRES QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ATOM QFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSL CC ************************************************** CC SEQRES SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ATOM SSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMD CC ************************************************** CC SEQRES ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ATOM ICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIIS CC ************************************************** CC SEQRES NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ATOM NEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMP CC ************************************************** CC SEQRES GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ATOM GGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPG CC ************************************************** CC SEQRES LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ATOM LPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWY CC ************************************************** CC SEQRES QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ATOM QMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVA CC ************************************************** CC SEQRES SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ATOM SFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAI CC ************************************************** CC SEQRES WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ATOM WGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTP CC ************************************************** CC SEQRES EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ATOM EDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDV CC ************************************************** CC SEQRES GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC ATOM GVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP CC **************************************** SQ SEQUENCE 740 AA; MW; CN; ADPGGSHHHH HHSRKTYTLT DYLKNTYRLK LYSLRWISDH EYLYKQENNI LVFNAEYGNS SVFLENSTFD EFGHSINDYS ISPDGQFILL EYNYVKQWRH SYTASYDIYD LNKRQLITEE RIPNNTQWVT WSPVGHKLAY VWNNDIYVKI EPNLPSYRIT WTGKEDIIYN GITDWVYEEE VFSAYSALWW SPNGTFLAYA QFNDTEVPLI EYSFYSDESL QYPKTVRVPY PKAGAVNPTV KFFVVNTDSL SSVTNATSIQ ITAPASMLIG DHYLCDVTWA TQERISLQWL RRIQNYSVMD ICDYDESSGR WNCLVARQHI EMSTTGWVGR FRPSEPHFTL DGNSFYKIIS NEEGYRHICY FQIDKKDCTF ITKGTWEVIG IEALTSDYLY YISNEYKGMP GGRNLYKIQL SDYTKVTCLS CELNPERCQY YSVSFSKEAK YYQLRCSGPG LPLYTLHSSV NDKGLRVLED NSALDKMLQN VQMPSKKLDF IILNETKFWY QMILPPHFDK SKKYPLLLDV YAGPCSQKAD TVFRLNWATY LASTENIIVA SFDGRGSGYQ GDKIMHAINR RLGTFEVEDQ IEAARQFSKM GFVDNKRIAI WGWSYGGYVT SMVLGSGSGV FKCGIAVAPV SRWEYYDSVY TERYMGLPTP EDNLDHYRNS TVMSRAENFK QVEYLLIHGT ADDNVHFQQS AQISKALVDV GVDFQAMWYT DEDHGIASST AHQHIYTHMS HFIKQCFSLP //