Brand  (β version)

PDB ID: 1MOX

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CD Cadmium ion PoSSuM
CL Chloride ion PoSSuM
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose PoSSuM
PT Platinum (II) ion PoSSuM
Modified Residues
Code Name Link
BMA Beta-D-mannopyranose PoSSuM
FUC Alpha-L-fucopyranose PoSSuM
MAN Alpha-D-mannopyranose PoSSuM

Structure summary

Code : 1MOX   PDBj   RCSB PDB   PDBe
Header : transferase/growth factor
Title : Crystal Structure of Human Epidermal Growth Factor Receptor (residues 1-501) in complex with TGF-alpha
Release Data : 2003-09-10
Compound :
mol_id molecule chains
1 Epidermal Growth Factor Receptor A,B
ec: 2.7.1.112
fragment: Extracellular Fragment
mol_id molecule chains
2 Transforming Growth Factor alpha C,D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: EGFR
expression_system_common: Chinese hamster
expression_system_cell_line: Lec8
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TGFA
Authors : Garrett, T.P.J., McKern, N.M., Lou, M., Elleman, T.C., Adams, T.E., Lovrecz, G.O., Zhu, H.-J., Walker, F., Frenkel, M.J., Hoyne, P.A., Jorissen, R.N., Nice, E.C., Burgess, A.W., Ward, C.W.
Keywords : EGFR, Receptor, Complex, Growth Factor, transferase-growth factor COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Crystal Structure of a Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor alpha

Garrett, T.P.J.,McKern, N.M.,Lou, M.  et al.
(2002)  Cell(Cambridge,Mass.)  110 : 763 - 773

PubMed: 12297049
DOI: 10.1016/S0092-8674(02)00940-6

Reaction

Chain : A, B
UniProt : P00533 (EGFR_HUMAN)
Reaction : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Chain : C, D
UniProt : P01135 (TGFA_HUMAN)
Reaction : -