Brand  (β version)

PDB ID: 7W7G

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 7W7G   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Structure of Mammalian NALCN-FAM155A-UNC79-UNC80 quanternary complex
Release Data : 2022-05-18
Compound :
mol_id molecule chains synonym
1 Protein unc-79 homolog A UNC79
mol_id molecule chains
2 Protein unc-80 homolog B
mol_id molecule chains synonym
3 Sodium leak channel non-selective protein C Four domain-type voltage-gated ion channel alpha-1 subunit,Rb21-channel,Voltage gated channel-like protein 1
mol_id molecule chains
4 Transmembrane protein FAM155A D
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Homo sapiens  (taxid:9606)
gene: Unc79
mol_id organism_scientific organism_common expression_system
2 Mus musculus  (taxid:10090) House mouse Homo sapiens  (taxid:9606)
mol_id organism_scientific organism_common expression_system
3 Rattus norvegicus  (taxid:10116) Norway rat Homo sapiens  (taxid:9606)
gene: Nalcn, Nca, Rb21, Vgcnl1
mol_id organism_scientific organism_common expression_system
4 Mus musculus  (taxid:10090) House mouse Homo sapiens  (taxid:9606)
gene: Fam155a
Authors : Chen, L., Kang, Y.
Keywords : Sodium leak channel, NALCN, channel, FAM155, UNC79, UNC80, MEMBRANE PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 3.2 Å )
Citation :

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex.

Kang, Y.,Chen, L.
(2022)  Nat Commun  13 : 2639 - 2639

PubMed: 35550517
DOI: 10.1038/s41467-022-30403-7

Reaction

Chain : A
UniProt : E5CYJ9 (E5CYJ9_MOUSE)
Reaction : -
Chain : B
UniProt : B8XCJ6
Reaction : -
Chain : C
UniProt : Q6Q760 (NALCN_RAT)
Reaction: EC: Evidence:
Physiological Direction:
Na(+)(in) = Na(+)(out) - UniProtKB:Q8IZF0
-
Chain : D
UniProt : Q8CCS2 (NALF1_MOUSE)
Reaction : -