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Code Name Link
FKE 4-(4-phenylpiperidin-1-yl)carbonylbenzenesulfonamide
ZN Zinc ion
Code : 6H36   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : The crystal structure of human carbonic anhydrase VII in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 Carbonic anhydrase 7 A Carbonate dehydratase VII,Carbonic anhydrase VII,CA-VII
mutation: C183S, C217S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CA7
Authors : Buemi, M.R., Di Fiore, A., De Luca, L., Ferro, S., Mancuso, F., Monti, S.M., Buonanno, M., Angeli, A., Russo, E., De Sarro, G., Supuran, C.T., De Simone, G., Gitto, R.
Keywords : Protein-Inhibitor binding, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

Buemi, M.R.,Di Fiore, A.,De Luca, L.  et al.
(2018)  Eur J Med Chem  163 : 443 - 452

PubMed: 30530195
DOI: 10.1016/j.ejmech.2018.11.073

Chain : A
UniProt : P43166 (CAH7_HUMAN)
Reaction : Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=;