Brand  (β version)

PDB ID: 6ZS2

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Ligands
Code Name Style Show Link
FX5 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 6ZS2   PDBj   RCSB PDB   PDBe
Header : GENE REGULATION
Title : Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol
Release Data : 2020-10-07
Compound :
mol_id molecule chains synonym
1 Transcription activator BRG1 A,B ATP-dependent helicase SMARCA4,BRG1-associated factor 190A,BAF190A,Mitotic growth and transcription activator,Protein BRG-1,Protein brahma homolog 1,SNF2-beta,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
ec: 3.6.4.-
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: SMARCA4, BAF190A, BRG1, SNF2B, SNF2L4
Authors : Preuss, F., Joerger, A.C., Kraemer, A., Wanior, M., Knapp, S., Structural Genomics Consortium (SGC)
Keywords : BROMODOMAIN, ATP-DEPENDENT HELICASE SMARCA4, BRG1-ASSOCIATED FACTOR 190A, BAF190A, MITOTIC GROWTH AND TRANSCRIPTION ACTIVATOR, PROTEIN BRG-1, PROTEIN BRAHMA HOMOLOG 1, SNF2-BETA, SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 4, STRUCTURAL GENOMICS CONSORTIUM, SGC, TRANSCRIPTION, GENE REGULATION
Exp. method : X-RAY DIFFRACTION ( 1.57 Å )
Citation :

Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.

Wanior, M.,Preuss, F.,Ni, X.  et al.
(2020)  J.Med.Chem.  63 : 14680 - 14699

PubMed: 33216538
DOI: 10.1021/acs.jmedchem.0c01242

Reaction

Chain : A, B
UniProt : P51532 (SMCA4_HUMAN)
Reaction : -