Het-PDB Navi2 (PDB: 6X3U)

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Ligands
Code	Name		Style	Show	Link
ABU	Gamma-amino-butanoic acid				PoSSuM
FYP	Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize
BMA	Beta-D-mannopyranose
MAN	Alpha-D-mannopyranose
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
Code	Name	Show

Download interaction data: 6X3U

Code :

6X3U PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN

Title :

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil

Release Data :

2020-09-09

Compound :

mol_id	molecule	chains	synonym
1	Gamma-aminobutyric acid receptor subunit beta-2	A,C	GABA(A) receptor subunit beta-2

mol_id	molecule	chains	synonym
2	Gamma-aminobutyric acid receptor subunit alpha-1	B,D	GABA(A) receptor subunit alpha-1

mol_id	molecule	chains	synonym
3	Gamma-aminobutyric acid receptor subunit gamma-2	E	GABA(A) receptor subunit gamma-2

mol_id	molecule	chains
4	Kappa Fab Light Chain	I,L

mol_id	molecule	chains
5	IgG2b Fab Heavy Chain	J,K

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: GABRB2 expression_system_variant: GnTI- expression_system_cell_line: HEK293S expression_system_atcc_number: CRL-3022 expression_system_plasmid: pEZT-BM

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: GABRA1 expression_system_variant: GnTI- expression_system_cell_line: HEK293S expression_system_atcc_number: CRL-3022 expression_system_plasmid: pEZT-BM

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: GABRG2 expression_system_variant: GnTI- expression_system_cell_line: HEK293S expression_system_atcc_number: CRL-3022 expression_system_plasmid: pEZT-BM

mol_id	organism_scientific
4	Mus musculus (taxid:10090)

mol_id	organism_scientific
5	Mus musculus (taxid:10090)

Authors :

Kim, J.J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R.J., Zhu, S., Noviello, C.M., Walsh, R.M., Lindahl, E., Hibbs, R.E.

Keywords :

Ion channel, Cys-loop receptor, pentametic ligand gated channel, GABAA receptor, TRANSPORT PROTEIN

Exp. method :

ELECTRON MICROSCOPY ( 3.5 Å )

Citation :

Shared structural mechanisms of general anaesthetics and benzodiazepines.

Kim, J.J.,Gharpure, A.,Teng, J. et al.
(2020) Nature 585 : 303 - 308

PubMed: 32879488
DOI: 10.1038/s41586-020-2654-5

Chain :

A, C

UniProt :

P47870 (GBRB2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
chloride(in) = chloride(out)	-	UniProtKB:P08219
chloride(in) = chloride(out)	-	UniProtKB:P08219

Chain :

B, D

UniProt :

P14867 (GBRA1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
chloride(in) = chloride(out)	-	PubMed:23909897, PubMed:29950725, PubMed:30602789
chloride(in) = chloride(out)	-	PubMed:23909897, PubMed:29950725, PubMed:30602789

Chain :

UniProt :

P18507 (GBRG2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
chloride(in) = chloride(out)	-	PubMed:14993607, PubMed:16412217, PubMed:2538761, PubMed:27864268, PubMed:29950725, PubMed:30602789
chloride(in) = chloride(out)	-

PDB ID: 6X3U

Hetero Atom Contents

Structure summary

Reaction