Brand  (β version)

PDB ID: 6S0Q

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Ligands
Code Name Style Show Link
CLR Cholesterol PoSSuM
OLA Oleic acid PoSSuM
OLB (2s)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
OLC (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate PoSSuM
ZMA 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol PoSSuM
Non-standard Residues
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Structure summary

Code : 6S0Q   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from 50,000 diffraction patterns
Release Data : 2020-07-15
Compound :
mol_id molecule chains synonym
1 Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a A Cytochrome b-562
mutation: ADORA2A,ADORA2A,ADORA2A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
gene: ADORA2A, ADORA2
Authors : Nass, K., Cheng, R., Vera, L., Mozzanica, A., Redford, S., Ozerov, D., Basu, S., James, D., Knopp, G., Cirelli, C., Martiel, I., Casadei, C., Weinert, T., Nogly, P., Skopintsev, P., Usov, I., Leonarski, F., Geng, T., Rappas, M., Dore, A.S., Cooke, R., Nasrollahi Shirazi, S., Dworkowski, F., Sharpe, M., Olieric, N., Steinmetz, M.O., Schertler, G., Abela, R., Patthey, L., Schmitt, B., Hennig, M., Standfuss, J., Wang, M., Milne, J.C.
Keywords : native-SAD, Serial femtosecond crystallography, SFX, SwissFEL, membrane protein
Exp. method : X-RAY DIFFRACTION ( 2.650 Å )
Citation :

Advances in long-wavelength native phasing at X-ray free-electron lasers.

Nass, K.,Cheng, R.,Vera, L.  et al.
(2020)  Iucrj  7 : 965 - 975

PubMed: 33209311
DOI: 10.1107/S2052252520011379

Reaction

Chain : A
UniProt : P29274 (AA2AR_HUMAN)
Reaction : -
Chain : A
UniProt : P0ABE7 (C562_ECOLX)
Reaction : -
Cofactor: Evidence: Note:
heme b - Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.