Brand  (β version)

PDB ID: 6P7U

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Ligands
Code Name Style Show Link
FTJ (2r)-2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 6P7U   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CRYSTAL STRUCTURE OF THE CARBOXYLTRANSFERASE SUBUNIT OF ACC (ACCD6) IN COMPLEX WITH INHIBITOR QUIZALOFOP-P FROM MYCOBACTERIUM TUBERCULOSIS
Release Data : 2020-06-10
Compound :
mol_id molecule chains synonym
1 Probable propionyl-CoA carboxylase beta chain 6 A,B,C,D PCCase,Propanoyl-CoA:carbon dioxide ligase
ec: 6.4.1.3
mutation: 0
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)  (taxid:83332) Escherichia coli BL21(DE3)  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: accD6, Rv2247, MTCY427.28
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET28
Authors : Reddy, M.C.M., Sacchettini, J.C., Center for Structural Genomics of Infectious Diseases (CSGID)
Keywords : CROTONASE SUPER FAMILY, CARBOXYLTRANSFERASE, TRANSFERASE-HERBICIDE, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.1980 Å )
Citation :

Inhibition of Mycobacterium tuberculosis acetyl-CoA carboxyltransferase(AccD6)d omain of acetyl-coenzyme A carboxylase by quizalofop-p

Reddy, M.C.M.,Sacchettini, J.C.
To Be Published 

Structure, Activity, and Inhibition of the Carboxyltransferase beta-Subunit of Acetyl Coenzyme A Carboxylase (AccD6) from Mycobacterium tuberculosis

Reddy, M.C.M.,Sacchettini, J.C.
(2014)  Antimicrob.Agents Chemother. 

PubMed: 25092705
DOI: 10.1128/AAC.02574-13

Reaction

Chain : A, B, C, D
UniProt : P9WQH5 (ACCD6_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl- CoA + N(6)-biotinyl-L-lysyl-[protein] 2.1.3.15 PubMed:17114269, PubMed:25092705
left-to-right PubMed:17114269
N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein] - PubMed:17114269
left-to-right