Brand  (β version)

PDB ID: 6MYQ

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Ligands
Code Name Style Show Link
3PE 1,2-diacyl-sn-glycero-3-phosphoethanolamine PoSSuM
9AU 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one PoSSuM
F3S Fe3-s4 cluster PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
K Potassium ion PoSSuM
MOH Methanol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
SF4 Iron/sulfur cluster PoSSuM
UMQ Undecyl-maltoside PoSSuM
UNL Unknown ligand PoSSuM
Y3P (~{z})-2-oxidanylbut-2-enedioic acid PoSSuM
Non-standard Residues
Code Name Show
MLZ N-methyl-lysine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 6MYQ   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR
Title : Avian mitochondrial complex II with ferulenol bound
Release Data : 2019-11-06
Compound :
mol_id molecule chains
1 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial A
ec: 1.3.5.1
mol_id molecule chains synonym
2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial B Iron-sulfur subunit of complex II,Ip
ec: 1.3.5.1
mol_id molecule chains
3 Succinate dehydrogenase cytochrome b, large subunit C
ec: 1.3.5.1
mol_id molecule chains synonym
4 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial D CybS,Succinate dehydrogenase complex subunit D,Succinate-ubiquinone oxidoreductase cytochrome b small subunit,Succinate-ubiquinone reductase membrane anchor subunit
Source :
mol_id organism_scientific organism_common
1 Gallus gallus  (taxid:9031) Chicken
organ: heart
mol_id organism_scientific organism_common
2 Gallus gallus  (taxid:9031) Chicken
organ: heart
mol_id organism_scientific organism_common
3 Gallus gallus  (taxid:9031) Chicken
organ: heart
mol_id organism_scientific organism_common
4 Gallus gallus  (taxid:9031) Chicken
organ: heart
Authors : Berry, E.A., Huang, L.-S.
Keywords : Complex II, membrane protein, heme protein, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.97 Å )
Citation :

Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.

Huang, L.S.,Lummen, P.,Berry, E.A.
(2021)  Biochim Biophys Acta Proteins Proteom  1869 : 140679 - 140679

PubMed: 34089891
DOI: 10.1016/j.bbapap.2021.140679

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme.

Huang, L.S.,Sun, G.,Cobessi, D.  et al.
(2006)  J. Biol. Chem.  281 : 5965 - 5972

PubMed: 16371358
DOI: 10.1074/jbc.M511270200

Crystallographic studies of the binding of ligands to the dicarboxylate site of Complex II, and the identity of the ligand in the "oxaloacetate-inhibited" state.

Huang, L.S.,Shen, J.T.,Wang, A.C.  et al.
(2006)  Biochim. Biophys. Acta  1757 : 1073 - 1083

PubMed: 16935256
DOI: 10.1016/j.bbabio.2006.06.015

Crystallization of mitochondrial respiratory complex II from chicken heart: a membrane-protein complex diffracting to 2.0 A.

Huang, L.S.,Borders, T.M.,Shen, J.T.  et al.
(2005)  Acta Crystallogr. D Biol. Crystallogr.  61 : 380 - 387

PubMed: 15805592
DOI: 10.1107/S0907444905000181

Crystal structure of mitochondrial respiratory membrane protein complex II.

Sun, F.,Huo, X.,Zhai, Y.  et al.
(2005)  Cell  121 : 1043 - 1057

PubMed: 15989954
DOI: 10.1016/j.cell.2005.05.025

Reaction

Chain : A
UniProt : F1NPJ4
Reaction : -
Chain : B
UniProt : Q9YHT2 (SDHB_CHICK)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = a quinol + fumarate 1.3.5.1 UniProtKB:P21912
-
Chain : C
UniProt : D0VWW3 (D0VWW3_CHICK)
Reaction : -
Chain : D
UniProt : Q5ZIS0 (DHSD_CHICK)
Reaction : -