Brand  (β version)

PDB ID: 6JP5

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Ligands
Code Name Style Show Link
3PE 1,2-diacyl-sn-glycero-3-phosphoethanolamine PoSSuM
C5U Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate PoSSuM
CA Calcium ion PoSSuM
ETA Ethanolamine PoSSuM
PC1 1,2-diacyl-sn-glycero-3-phosphocholine PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
BMA Beta-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 6JP5   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Rabbit Cav1.1-Nifedipine Complex
Release Data : 2019-06-12
Compound :
mol_id molecule chains synonym
1 Voltage-dependent L-type calcium channel subunit alpha-1S A Calcium channel,L type,alpha-1 polypeptide,isoform 3,skeletal muscle,Voltage-gated calcium channel subunit alpha Cav1.1
mol_id molecule chains synonym
2 Voltage-dependent calcium channel gamma-1 subunit E Dihydropyridine-sensitive L-type,skeletal muscle calcium channel subunit gamma
mol_id molecule chains synonym
3 Voltage-dependent calcium channel subunit alpha-2/delta-1 F Voltage-gated calcium channel subunit alpha-2/delta-1
mol_id molecule chains synonym
4 Voltage-dependent L-type calcium channel subunit beta-1 B,C CAB1,Calcium channel voltage-dependent subunit beta 1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
2 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common
3 Oryctolagus cuniculus  (taxid:9986) Rabbit
mol_id organism_scientific organism_common expression_system
4 Oryctolagus cuniculus  (taxid:9986) Rabbit Escherichia coli  (taxid:562)
gene: CACNB1, CACNLB1
Authors : Zhao, Y., Huang, G., Wu, J., Yan, N.
Keywords : Membrane protein complex modulated by FDA approved drug., MEMBRANE PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 2.9 Å )
Citation :

Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.

Zhao, Y.,Huang, G.,Wu, J.  et al.
(2019)  Cell  177 : 1495 - 1506.e12

PubMed: 31150622
DOI: 10.1016/j.cell.2019.04.043

Reaction

Chain : A
UniProt : P07293 (CAC1S_RABIT)
Reaction : -
Chain : E
UniProt : P19518 (CCG1_RABIT)
Reaction : -
Chain : F
UniProt : P13806 (CA2D1_RABIT)
Reaction : -
Chain : B, C
UniProt : P19517 (CACB1_RABIT)
Reaction : -