Brand  (β version)

color scheme of protein:

chain:

Ligands
Code Name Link
9AU 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one
ACT Acetate ion
FMN Flavin mononucleotide
ORO Orotic acid
SO4 Sulfate ion
Code : 6IDJ   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of human DHODH in complex with ferulenol
Release Data : 2019-09-11
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
Authors : Shiba, T., Inaoka, D.K., Sato, D., Hartuti, E.D., Amalia, E., Nagahama, M., Yoshioka, Y., Matsubayashi, M., Balogun, E.O., Tsuji, N., Kita, K., Harada, S.
Keywords : Coccidium, mitochondria, electron transport chain, dihydroorotate dehydrogenase, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.

Sato, D.,Hartuti, E.D.,Inaoka, D.K.  et al.
(2020)  Genes (Basel)  11

PubMed: 33297567
DOI: 10.3390/genes11121468

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction : Reaction=(S)-dihydroorotate + a quinone = a quinol + orotate; Xref=Rhea:RHEA:30187, ChEBI:CHEBI:24646, ChEBI:CHEBI:30839, ChEBI:CHEBI:30864, ChEBI:CHEBI:132124; EC=1.3.5.2; Evidence={ECO:0000269|PubMed:8925840};