Brand  (β version)

PDB ID: 6IDJ

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Ligands
Code Name Style Show Link
9AU 4-oxidanyl-3-[(2~{E},6~{E})-3,7,11-trimethyldodeca-2,6,10-trienyl]chromen-2-one PoSSuM
ACT Acetate ion PoSSuM
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 6IDJ   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of human DHODH in complex with ferulenol
Release Data : 2019-09-11
Compound :
mol_id molecule chains synonym
1 Dihydroorotate dehydrogenase (quinone), mitochondrial A DHOdehase,Dihydroorotate oxidase
ec: 1.3.5.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: DHODH
Authors : Shiba, T., Inaoka, D.K., Sato, D., Hartuti, E.D., Amalia, E., Nagahama, M., Yoshioka, Y., Matsubayashi, M., Balogun, E.O., Tsuji, N., Kita, K., Harada, S.
Keywords : Coccidium, mitochondria, electron transport chain, dihydroorotate dehydrogenase, MEMBRANE PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.

Sato, D.,Hartuti, E.D.,Inaoka, D.K.  et al.
(2020)  Genes (Basel)  11

PubMed: 33297567
DOI: 10.3390/genes11121468

Reaction

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = a quinol + orotate 1.3.5.2 PubMed:8925840
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