Brand  (β version)

PDB ID: 6CNH

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Ligands
Code Name Style Show Link
919 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 6CNH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human PRPF4B in complex with Rebastinib
Release Data : 2018-03-28
Compound :
mol_id molecule chains synonym
1 Serine/threonine-protein kinase PRP4 homolog A PRPF4B, PRP4 kinase, PRP4 pre-mRNA-processing factor 4 homolog
ec: 2.7.11.1
fragment: UNP residues 657-1005
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
expression_system_common: Fall armyworm
Authors : Godoi, P.H.C., Santiago, A.S., Ramos, P.Z., Fala, A.M., Salmazo, A.P.T., Counago, R.M., Righetto, G.L., Silva, P.N.B., Gileadi, O., Guimaraes, C.R.W., Massirer, K.B., Arruda, P., Elkins, J.M., Edwards, A.M., Structural Genomics Consortium (SGC)
Keywords : Kinase, inhibitor, DCC2036, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Crystal structure of the human PRPF4B in complex with Rebastinib

Godoi, P.H.C.,Santiago, A.S.,Ramos, P.Z.  et al.
To be Published 

Reaction

Chain : A
UniProt : Q13523 (PRP4K_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) 2.7.11.1 PubMed:20118938, PubMed:21406692
left-to-right
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) 2.7.11.1 PubMed:10799319, PubMed:29695716
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