PDB ID: 6C57
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Structure summary
Code : | 6C57 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | Crystal structure of mutant human geranylgeranyl pyrophosphate synthase (Y246D) in complex with bisphosphonate inhibitor FV0109 | ||||||||||||
Release Data : | 2018-09-05 | ||||||||||||
Compound : |
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Source : |
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Authors : | Park, J., Bin, X., Vincent, F., Tsantrizos, Y.S., Berghuis, A.M. | ||||||||||||
Keywords : | ISOPRENOID PATHWAY, ISOPENTENYL TRANSFERASE, TRANSFERASE INHIBITOR, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 3.50 Å ) | ||||||||||||
Citation : |
Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.
Lacbay, C.M.,Waller, D.D.,Park, J.
et al.
PubMed: 30016091 |
Reaction
Chain : | A, B | ||||||||||||||||
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UniProt : | O95749 (GGPPS_HUMAN) | ||||||||||||||||
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