Brand  (β version)

PDB ID: 5ZYA

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
9B0 [(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate PoSSuM
K Potassium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5ZYA   PDBj   RCSB PDB   PDBe
Header : SPLICING
Title : SF3b spliceosomal complex bound to E7107
Release Data : 2018-06-20
Compound :
mol_id molecule chains synonym
1 Splicing factor 3B subunit 5 B SF3b5
mol_id molecule chains synonym
2 Splicing factor 3B subunit 1 C Pre-mRNA-splicing factor SF3b 155 kDa subunit,SF3b155
mol_id molecule chains synonym
3 PHD finger-like domain-containing protein 5A D PHD finger-like domain protein 5A
mol_id molecule chains synonym
4 Splicing factor 3B subunit 3 A Pre-mRNA-splicing factor SF3b 130 kDa subunit,SF3b130
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SF3B5
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SF3B1
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PHF5A
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: SF3B3
Authors : Finci, L.I., Larsen, N.A.
Keywords : Splicing Modulator, SF3b sub-complex, SPLICING
Exp. method : ELECTRON MICROSCOPY ( 3.95 Å )
Citation :

The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

Finci, L.I.,Zhang, X.,Huang, X.  et al.
(2018)  Genes Dev.  32 : 309 - 320

PubMed: 29491137
DOI: 10.1101/gad.311043.117

Reaction

Chain : B
UniProt : Q9BWJ5 (SF3B5_HUMAN)
Reaction : -
Chain : C
UniProt : O75533 (SF3B1_HUMAN)
Reaction : -
Chain : D
UniProt : Q7RTV0 (PHF5A_HUMAN)
Reaction : -
Chain : A
UniProt : Q15393 (SF3B3_HUMAN)
Reaction : -