Brand  (β version)

PDB ID: 5VJG

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Ligands
Code Name Style Show Link
0BP 2,2'-bipyridine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5VJG   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : horse liver alcohol dehydrogenase complexed with 2,2'bipyridine
Release Data : 2017-05-03
Compound :
mol_id molecule chains
1 Alcohol dehydrogenase E chain A
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common
1 Equus caballus  (taxid:9796) Horse
Authors : Plapp, B.V., Baskar Raj, S.
Keywords : alcohol dehydrogenase, 2, 2'bipyridine, horse liver, zinc chelation, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.9000 Å )
Citation :

Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis.

Plapp, B.V.,Savarimuthu, B.R.,Ferraro, D.J.  et al.
(2017)  Biochemistry  56 : 3632 - 3646

PubMed: 28640600
DOI: 10.1021/acs.biochem.7b00446

X-ray investigation of the binding of 1,10-phenanthroline and imidazole to horse-liver alcohol dehydrogenase.

Boiwe, T.,Branden, C.I.
(1977)  Eur. J. Biochem.  77 : 173 - 179

PubMed: 561693

Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 A resolution.

Eklund, H.,Nordstrom, B.,Zeppezauer, E.  et al.
(1976)  J. Mol. Biol.  102 : 27 - 59

PubMed: 178875

Reaction

Chain : A
UniProt : P00327 (ADH1E_HORSE)
Reaction: EC: Evidence:
Physiological Direction:
a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) 1.1.1.1 -
-
a secondary alcohol + NAD(+) = a ketone + NADH + H(+) 1.1.1.1 -
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:15299346
Binds 2 Zn(2+) ions per subunit.