Het-PDB Navi2 (PDB: 5V82)

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Ligands
Code	Name		Style	Show	Link
96Y	1-{6-[(3r)-4,4-difluoropiperidin-3-yl]pyridin-2-yl}-6-(6-methylpyrazin-2-yl)-1h-pyrazolo[4,3-C]pyridine				PoSSuM

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Download interaction data: 5V82

Code :

5V82 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/INHIBITOR

Title :

PIM1 kinase in complex with Cpd17 (1-(6-(4,4-difluoropiperidin-3-yl)pyridin-2-yl)-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-C]pyridine)

Release Data :

2017-05-10

Compound :

mol_id	molecule	chains
1	Serine/threonine-protein kinase pim-1	A
	ec: 2.7.11.1 fragment: UNP residues 29-313

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: PIM1 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid

Authors :

Murray, J.M., Wallweber, H.

Keywords :

PIM1, SBDD, TRANSFERASE-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 1.8880 Å )

Citation :

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

Wang, X.,Kolesnikov, A.,Tay, S. et al.
(2017) J. Med. Chem. 60 : 4458 - 4473

Chain :

UniProt :

P11309 (PIM1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394, PubMed:37797010
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:37797010
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:15525646 ECO:0000269 \| PubMed:15657054 ECO:0000269 \| PubMed:15808862	-

PDB ID: 5V82