Brand  (β version)

PDB ID: 5ODY

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Ligands
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9SK 5,6-bis(fluoranyl)-3-[[(2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,5-bis(oxidanyl)-4-[4-[3,4,5-tris(fluoranyl)phenyl]-1,2,3-triazol-1-yl]oxan-2-yl]sulfanyl-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one PoSSuM
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Structure summary

Code : 5ODY   PDBj   RCSB PDB   PDBe
Header : SUGAR BINDING PROTEIN
Title : Galectin-3C in complex with dithiogalactoside derivative
Release Data : 2018-05-23
Compound :
mol_id molecule chains synonym
1 Galectin-3 A Gal-3,35 kDa lectin,Carbohydrate-binding protein 35,CBP 35,Galactose-specific lectin 3,Galactoside-binding protein,GALBP,IgE-binding protein,L-31,Laminin-binding protein,Lectin L-29,Mac-2 antigen
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: LGALS3, MAC2
Authors : Kumar, R., Peterson, K., Nilsson, U.J., Logan, D.T.
Keywords : LECTIN, CARBOHYDRATE-BINDING PROTEIN, GALACTOSE-SPECIFIC LECTIN 3, GALACTOSIDE-BINDING PROTEIN, GALBP, IGE-6 BINDING PROTEIN, L-31, LAMININ-BINDING PROTEIN, LECTIN L-29, MAC-2, SUGAR BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.149 Å )
Citation :

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson, K.,Kumar, R.,Stenstrom, O.  et al.
(2018)  J. Med. Chem.  61 : 1164 - 1175

PubMed: 29284090
DOI: 10.1021/acs.jmedchem.7b01626

Reaction

Chain : A
UniProt : P17931 (LEG3_HUMAN)
Reaction : -