Het-PDB Navi2 (PDB: 5O1C)

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Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM
9GZ	5-(4-fluorophenyl)-3-iodanyl-2-oxidanyl-4-pyrrol-1-yl-benzoic acid				PoSSuM

Non-standard Residues
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Download interaction data: 5O1C

Code :

5O1C PDBj RCSB PDB PDBe

Header :

DNA BINDING PROTEIN

Title :

p53 cancer mutant Y220C in complex with compound MB184

Release Data :

2018-05-09

Compound :

mol_id	molecule	chains	synonym
1	Cellular tumor antigen p53	A,B	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
	fragment: UNP residues 94-312 mutation: M133L, V203A, Y220C, N239Y, N268D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: TP53, P53

Authors :

Joerger, A.C., Baud, M.G.J., Bauer, M.R., Fersht, A.R.

Keywords :

p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, DNA binding protein, molecular chaperones

Exp. method :

X-RAY DIFFRACTION ( 1.320 Å )

Citation :

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

Baud, M.G.J.,Bauer, M.R.,Verduci, L. et al.
(2018) Eur J Med Chem 152 : 101 - 114

Chain :

A, B

UniProt :

P04637 (P53_HUMAN)

Cofactor:	Evidence:	Note:
Reaction :	-
Zn(2+)	ECO:0000269 \| PubMed:14534297 ECO:0000269 \| PubMed:16793544 ECO:0000269 \| PubMed:17015838 ECO:0000269 \| PubMed:18650397 ECO:0000269 \| PubMed:19515728 ECO:0000269 \| PubMed:20142040 ECO:0000269 \| PubMed:20364130	Binds 1 zinc ion per subunit.

PDB ID: 5O1C