Brand  (β version)

PDB ID: 4ZVN

Hetero Atom Contents

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
AO Acridine orange PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ZN Zinc ion PoSSuM

Structure summary

Code : 4ZVN   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/oxidoreductase Inhibitor
Title : Reduced quinone reductase 2 in complex with acridine orange
Release Data : 2016-03-30
Compound :
mol_id molecule chains synonym
1 Ribosyldihydronicotinamide dehydrogenase [quinone] A,B NRH dehydrogenase [quinone] 2,NRH:quinone oxidoreductase 2,Quinone reductase 2,QR2
ec: 1.10.99.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: NQO2, NMOR2
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pProEXhta
Authors : Leung, K.K., Shilton, B.H.
Keywords : quinone reductase 2, acridine orange, Oxidoreductase-Inhibitor complex, Oxidoreductase-oxidoreductase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.8660 Å )
Citation :

Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2.

Leung, K.K.,Shilton, B.H.
(2015)  Biochemistry  54 : 7438 - 7448

PubMed: 26636353
DOI: 10.1021/acs.biochem.5b00884

Reaction

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction : Reaction=1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside; Xref=Rhea:RHEA:12364, ChEBI:CHEBI:15378, ChEBI:CHEBI:15927, ChEBI:CHEBI:24646, ChEBI:CHEBI:55458, ChEBI:CHEBI:132124; EC=1.10.5.1; Evidence={ECO:0000269|PubMed:18579530};