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Ligands
Code Name Link
933 2-cyclopropyl-N-[(2s)-3,3-dimethylbutan-2-yl]-5h-pyrrolo[2,3-B]pyrazine-7-carboxamide
PHU 1-phenylurea
Code : 4HVD   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-B]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide
Release Data : 2013-01-16
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein kinase JAK3 A Janus kinase 3, JAK-3, Leukocyte janus kinase, L-JAK
ec: 2.7.10.2
fragment: RESIDUES 811-1124
mutation: C1040S, C1048S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: JAK3
Authors : Kuglstatter, A., Shao, A.
Keywords : Kinase-Inhibitor Complex, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.85 Å )
Citation :

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.

Soth, M.,Hermann, J.C.,Yee, C.  et al.
(2013)  J.Med.Chem.  56 : 345 - 356

PubMed: 23214979
DOI: 10.1021/jm301646k

Chain : A
UniProt : P52333 (JAK3_HUMAN)
Reaction : Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};