PDB ID: 4B0C
Hetero Atom Contents
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Structure summary
Code : | 4B0C PDBj RCSB PDB PDBe | ||||||||||||
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Header : | LYASE | ||||||||||||
Title : | Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with 3-(pentylthio)-4H-1,2,4-triazole | ||||||||||||
Release Data : | 2012-11-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Moynie, L., McMahon, S.A., Duthie, F.G., Naismith, J.H. | ||||||||||||
Keywords : | LYASE, FATTY ACID BIOSYNTHESIS, BACTERIAL VIRULENCE, DRUG DISCOVERY | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.70 Å ) | ||||||||||||
Citation : |
Structural Insights Into the Mechanism and Inhibition of the Beta-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonasaeruginosa.
Moynie, L.,Leckie, S.M.,Mcmahon, S.A.
et al.
PubMed: 23174186 |
Reaction
Chain : | A, B, C, D, E |
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UniProt : | O33877 (FABA_PSEAE) |
Reaction : | Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O; Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945, ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59; Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O; Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639, ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467; Reaction=(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP]; Xref=Rhea:RHEA:23568, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9927, ChEBI:CHEBI:78467, ChEBI:CHEBI:78798; EC=5.3.3.14; |