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Code Name Link
ACT Acetate ion
CA Calcium ion
MG Magnesium ion
Modified Residues
Code Name Link
0A L-adenosine-5'-monophosphate
0C L-cytidine-5'-monophosphate
0DA 2'-deoxy-L-ribo-furanosyl adenosine-5'-monophosphate
0DC 2'-deoxy-L-ribo-furanosyl cytosine-5'-monophosphate
0DG 2'-deoxy-L-ribo-furanosyl guanine-5'-monophosphate
0G L-guanosine-5'-monophosphate
0U L-uridine-5'-monophosphate
3KA 1-(2-deoxy-5-O-phosphono-beta-L-erythro-pentofuranosyl)pyrimidine-2,4(1h,3h)-dione
Code : 4WB2   PDBj   RCSB PDB   PDBe
Title : Crystal structure of the mirror-image L-RNA/L-DNA aptamer NOX-D20 in complex with mouse C5a complement anaphylatoxin
Release Data : 2015-05-06
Compound :
mol_id molecule chains synonym
1 Complement C5 A,B,C Hemolytic complement
mol_id molecule chains
2 mixed L-RNA/L-DNA mirror-image aptamer NOX-D20 (40-MER) D,E
other_details: All DNA and RNA nucleotides of the entity are in the L-conformation
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House Mouse Escherichia coli  (taxid:562)
gene: C5, Hc
expression_system_strain: Shuffle T7 Express
expression_system_vector_type: plasmid
expression_system_plasmid: pET32a
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Yatime, L., Maasch, C., Hoehlig, K., Klussmann, S., Vater, A., Andersen, G.R.
Keywords : protein-RNA complex, mirror-image aptamer, G-quadruplex, complement anaphylatoxin, DNA-RNA hybrid
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.

Yatime, L.,Maasch, C.,Hoehlig, K.  et al.
(2015)  Nat Commun  6 : 6481 - 6481

PubMed: 25901944
DOI: 10.1038/ncomms7481

Chain : A, B, C
UniProt : P06684 (CO5_MOUSE)
Reaction : -