Brand  (β version)

PDB ID: 4MBH

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0RJ 3-(formylamino)-L-alanine PoSSuM
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
MA4 Cyclohexyl-hexyl-beta-D-maltoside PoSSuM

Structure summary

Code : 4MBH   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Penam sulfone PSR-3-226 bound to E166A variant of SHV-1 beta-lactamase
Release Data : 2014-07-30
Compound :
mol_id molecule chains synonym
1 Beta-lactamase SHV-1 A PIT-2
ec: 3.5.2.6
fragment: SHV-1 beta-lactamase
mutation: E166A
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: bla, shv1
Authors : Rodkey, E.A., van den Akker, F.
Keywords : Class A beta-lactamase, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.22 Å )
Citation :

Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.

Rodkey, E.A.,Winkler, M.L.,Bethel, C.R.  et al.
(2014)  Plos One  9 : e85892 - e85892

PubMed: 24454944
DOI: 10.1371/journal.pone.0085892

Reaction

Chain : A
UniProt : P0AD64 (BLA1_KLEPN)
Reaction : Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000255|PROSITE- ProRule:PRU10101};