Brand  (β version)

PDB ID: 4GG5

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0J3 3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine PoSSuM

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Structure summary

Code : 4GG5   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Crystal structure of CMET in complex with novel inhibitor
Release Data : 2012-10-03
Compound :
mol_id molecule chains synonym
1 Hepatocyte growth factor receptor A HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
ec: 2.7.10.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: c-MET, MET
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Liu, Q.F., Chen, T.T., Xu, Y.C.
Keywords : CMET inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.423 Å )
Citation :

Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.

Wu, K.,Ai, J.,Liu, Q.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 6368 - 6372

PubMed: 22985853
DOI: 10.1016/j.bmcl.2012.08.075

Reaction

Chain : A
UniProt : P08581 (MET_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+) 2.7.10.1 PROSITE-ProRule:PRU10028
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