Het-PDB Navi2 (PDB: 4GG5)

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Ligands
Code	Name		Style	Show	Link
0J3	3-(4-methylpiperazin-1-yl)-N-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine				PoSSuM

Non-standard Residues
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Download interaction data: 4GG5

Code :

4GG5 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of CMET in complex with novel inhibitor

Release Data :

2012-10-03

Compound :

mol_id	molecule	chains	synonym
1	Hepatocyte growth factor receptor	A	HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
	ec: 2.7.10.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: c-MET, MET expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Liu, Q.F., Chen, T.T., Xu, Y.C.

Keywords :

CMET inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.423 Å )

Citation :

Multisubstituted quinoxalines and pyrido[2,3-d]pyrimidines: Synthesis and SAR study as tyrosine kinase c-Met inhibitors.

Wu, K.,Ai, J.,Liu, Q. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 6368 - 6372

Chain :

UniProt :

P08581 (MET_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)	2.7.10.1	PROSITE-ProRule:PRU10028
	-	PROSITE-ProRule:PRU10028

PDB ID: 4GG5