Brand  (β version)

PDB ID: 4GAH

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Ligands
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0ET [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3r)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-[(2r)-2-oxidanylundecyl]sulfanylethylamino]propyl]amino]butyl] hydrogen phosphate PoSSuM
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Structure summary

Code : 4GAH   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor
Release Data : 2012-08-29
Compound :
mol_id molecule chains synonym
1 Thioesterase superfamily member 4 A,B Carboxyl-terminal modulator protein
ec: 3.1.2.20
fragment: residues 40-240
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CTMP, THEM4
expression_system_strain: BL21codon plus(DE3) RIL
expression_system_vector_type: plasmid
expression_system_plasmid: pET-23a
Authors : Lim, K., Pathak, M.C., Herzberg, O.
Keywords : hotdog fold, acyl CoA hydrolase; akt c-terminal modulating protein, acyl-CoA, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Correlation of structure and function in the human hotdog-fold enzyme hTHEM4.

Zhao, H.,Lim, K.,Choudry, A.  et al.
(2012)  Biochemistry  51 : 6490 - 6492

PubMed: 22871024
DOI: 10.1021/bi300968n

The Akt C-Terminal modulator protein is an acyl-CoA thioesterase of the hotdog-fold family

Zhao, H.,Martin, B.,Bisoffi, M.  et al.
(2009)  Biochemistry  48 : 5507 - 5509

Reaction

Chain : A, B
UniProt : Q5T1C6 (THEM4_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+) 3.1.2.2 PubMed:19453107, PubMed:22871024
left-to-right PubMed:19453107
octanoyl-CoA + H2O = octanoate + CoA + H(+) - PubMed:19453107
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decanoyl-CoA + H2O = decanoate + CoA + H(+) - PubMed:19453107
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dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+) - PubMed:19453107
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tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+) - PubMed:19453107
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(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+) - PubMed:19453107
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(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + CoA + H(+) - PubMed:19453107
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