Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
0VD (3s)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1h-imidazol-4-yl)butan-2-one
DMS Dimethyl sulfoxide
GOL Glycerol
ZN Zinc ion
Code : 4G09   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/Oxidoreductase inhibitor
Title : The crystal structure of the C366S mutant of HDH from Brucella suis in complex with a substituted benzyl ketone
Release Data : 2013-10-02
Compound :
mol_id molecule chains synonym
1 Histidinol dehydrogenase A HDH
ec: 1.1.1.23
mutation: C366S
Source :
mol_id organism_scientific expression_system
1 Brucella suis  (taxid:204722) Escherichia coli  (taxid:562)
strain: 1330
gene: hisD, BR0252, BS1330_I0253
Authors : D'Ambrosio, K., De Simone, G.
Keywords : Rossmann Fold, L-HISTIDINOL DEHYDROGENASE, Oxidoreductase-Oxidoreductase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis.

D'ambrosio, K.,Lopez, M.,Dathan, N.A.  et al.
(2014)  Biochimie  97 : 114 - 120

PubMed: 24140957
DOI: 10.1016/j.biochi.2013.09.028

Chain : A
UniProt : Q8G2R2 (HISX_BRUSU)
Reaction : Reaction=H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH; Xref=Rhea:RHEA:20641, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57595, ChEBI:CHEBI:57699, ChEBI:CHEBI:57945; EC=1.1.1.23; Evidence={ECO:0000255|HAMAP- Rule:MF_01024};