Brand  (β version)

PDB ID: 4G09

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Ligands
Code Name Style Show Link
0VD (3s)-3-amino-1-[4-(benzyloxy)phenyl]-4-(1h-imidazol-4-yl)butan-2-one PoSSuM
DMS Dimethyl sulfoxide PoSSuM
GOL Glycerol PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 4G09   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/Oxidoreductase inhibitor
Title : The crystal structure of the C366S mutant of HDH from Brucella suis in complex with a substituted benzyl ketone
Release Data : 2013-10-02
Compound :
mol_id molecule chains synonym
1 Histidinol dehydrogenase A HDH
ec: 1.1.1.23
mutation: C366S
Source :
mol_id organism_scientific expression_system
1 Brucella suis  (taxid:204722) Escherichia coli  (taxid:562)
strain: 1330
gene: hisD, BR0252, BS1330_I0253
Authors : D'Ambrosio, K., De Simone, G.
Keywords : Rossmann Fold, L-HISTIDINOL DEHYDROGENASE, Oxidoreductase-Oxidoreductase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis.

D'ambrosio, K.,Lopez, M.,Dathan, N.A.  et al.
(2014)  Biochimie  97 : 114 - 120

PubMed: 24140957
DOI: 10.1016/j.biochi.2013.09.028

Reaction

Chain : A
UniProt : Q8G2R2 (HISX_BRUSU)
Reaction: EC: Evidence:
Physiological Direction:
L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+) 1.1.1.23 HAMAP-Rule:MF_01024
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000255 | HAMAP-Rule:MF_01024
Binds 1 zinc ion per subunit.