Het-PDB Navi2 (PDB: 4F7N)

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Ligands
Code	Name		Style	Show	Link
0SV	1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5-hydroxypentyl)urea				PoSSuM
EDO	1,2-ethanediol				PoSSuM

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Download interaction data: 4F7N

Code :

4F7N PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSCRIPTION/INHIBITOR

Title :

Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea)

Release Data :

2013-05-01

Compound :

mol_id	molecule	chains	synonym
1	Cyclin-dependent kinase 8	A	Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35
	ec: 2.7.11.22, 2.7.11.23 fragment: UNP residues 1-403

mol_id	molecule	chains	synonym
2	Cyclin-C	B	SRB11 homolog, hSRB11

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CDK8 expression_system_common: Fall armyworm expression_system_vector_type: baculovirus

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CCNC expression_system_common: Fall armyworm expression_system_vector_type: baculovirus

Authors :

Schneider, E.V., Boettcher, J., Huber, R., Maskos, K.

Keywords :

protein kinase complex, Proteros, TRANSFERASE-TRANSCRIPTION-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.65 Å )

Citation :

Structure-kinetic relationship study of CDK8/CycC specific compounds.

Schneider, E.V.,Bottcher, J.,Huber, R. et al.
(2013) Proc.Natl.Acad.Sci.USA 110 : 8081 - 8086

Chain :

UniProt :

P49336 (CDK8_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.22	PubMed:10993082
	-	PubMed:10993082
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.22	PubMed:10993082
	-	PubMed:10993082
[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)	2.7.11.23	PubMed:10993082
	-	PubMed:10993082
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000250	-

PDB ID: 4F7N