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interaction residue:

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Code Name Link
0SV 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5-hydroxypentyl)urea
EDO 1,2-ethanediol
Code : 4F7N   PDBj   RCSB PDB   PDBe
Title : Crystal structure of human CDK8/CYCC in complex with compound 11 (1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-(5-hydroxypentyl)urea)
Release Data : 2013-05-01
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 8 A Cell division protein kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8, Protein kinase K35
fragment: UNP residues 1-403
mol_id molecule chains synonym
2 Cyclin-C B SRB11 homolog, hSRB11
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CDK8
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: CCNC
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
Authors : Schneider, E.V., Boettcher, J., Huber, R., Maskos, K.
Keywords : protein kinase complex, Proteros, TRANSFERASE-TRANSCRIPTION-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.65 Å )
Citation :

Structure-kinetic relationship study of CDK8/CycC specific compounds.

Schneider, E.V.,Bottcher, J.,Huber, R.  et al.
(2013)  Proc.Natl.Acad.Sci.USA  110 : 8081 - 8086

PubMed: 23630251
DOI: 10.1073/pnas.1305378110

Chain : A
UniProt : P49336 (CDK8_HUMAN)
Reaction : Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=; Evidence={ECO:0000269|PubMed:10993082};
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=; Evidence={ECO:0000269|PubMed:10993082};
Reaction=[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho- [DNA-directed RNA polymerase]; Xref=Rhea:RHEA:10216, Rhea:RHEA- COMP:11321, Rhea:RHEA-COMP:11322, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43176, ChEBI:CHEBI:68546, ChEBI:CHEBI:456216; EC=; Evidence={ECO:0000269|PubMed:10993082};
Chain : B
UniProt : P24863 (CCNC_HUMAN)
Reaction : -