PDB ID: 4EDZ
Hetero Atom Contents
color scheme of protein:
hetatm:
x
information
centroid:
interaction residue:
chain: Hide other chain(s)
Structure summary
Code : | 4EDZ PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | Isomerase/Isomerase inhibitor | ||||||||||||
Title : | Crystal structure of hH-PGDS with water displacing inhibitor | ||||||||||||
Release Data : | 2012-05-16 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Day, J.E., Thorarensen, A., Trujillo, J.I. | ||||||||||||
Keywords : | Inhibitor, Solvent replacement, Isomerase-Isomerase inhibitor complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.0000 Å ) | ||||||||||||
Citation : |
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters.
Trujillo, J.I.,Kiefer, J.R.,Huang, W.
et al.
PubMed: 22546671 |
Reaction
Chain : | A, B, C, D |
---|---|
UniProt : | O60760 (HPGDS_HUMAN) |
Reaction : | Reaction=prostaglandin H2 = prostaglandin D2; Xref=Rhea:RHEA:10600, ChEBI:CHEBI:57405, ChEBI:CHEBI:57406; EC=5.3.99.2; Evidence={ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:12244105, ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:19939518, ECO:0000269|PubMed:9353279, ECO:0000269|PubMed:9425264}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10601; Evidence={ECO:0000305|PubMed:10824118, ECO:0000305|PubMed:12244105}; Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:10824118, ECO:0000269|PubMed:11672424, ECO:0000269|PubMed:15113825}; Reaction=2-glyceryl-prostaglandin H2 = 2-glyceryl-prostaglandin D2; Xref=Rhea:RHEA:51232, ChEBI:CHEBI:85166, ChEBI:CHEBI:133979; Evidence={ECO:0000269|PubMed:12244105}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:51233; Evidence={ECO:0000305|PubMed:12244105}; |