PDB ID: 4E6Q
Hetero Atom Contents
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Structure summary
Code : | 4E6Q PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | JAK2 kinase (JH1 domain) triple mutant in complex with compound 12 | ||||||||||||
Release Data : | 2012-05-30 | ||||||||||||
Compound : |
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Source : |
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Authors : | Murray, J.M. | ||||||||||||
Keywords : | JAK2, kinase domain, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.9480 Å ) | ||||||||||||
Citation : |
Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors.
Kulagowski, J.J.,Blair, W.,Bull, R.J.
et al.
PubMed: 22591402 |
Reaction
Chain : | A, B |
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UniProt : | O60674 (JAK2_HUMAN) |
Reaction : | Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:9618263}; |