PDB ID: 4E3J
Hetero Atom Contents
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Structure summary
Code : | 4E3J PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE/HYDROLASE INHIBITOR | ||||||||||||
Title : | Crystal structure of AmpC beta-lactamase in complex with a designed 4-tetrazolyl benzene sulfonamide boronic acid inhibitor | ||||||||||||
Release Data : | 2012-09-26 | ||||||||||||
Compound : |
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Source : |
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Authors : | Eidam, O., Shoichet, B.K. | ||||||||||||
Keywords : | AMPC beta-lactamase, class c, hydrolase, cephalosporinase, HYDROLASE-HYDROLASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.7999 Å ) | ||||||||||||
Citation : |
Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo.
Eidam, O.,Romagnoli, C.,Dalmasso, G.
et al.
PubMed: 23043117 |
Reaction
Chain : | A, B |
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UniProt : | P00811 (AMPC_ECOLI) |
Reaction : | Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000255|PROSITE- ProRule:PRU10102}; |