Het-PDB Navi2 (PDB: 4D8Z)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
SO4	Sulfate ion				PoSSuM
0J2	(3r)-3-(7-amino-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-C]pyridazin-3-yl)butanoic acid				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 4D8Z

Code :

4D8Z PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Crystal structure of B. anthracis DHPS with compound 24

Release Data :

2012-03-28

Compound :

mol_id	molecule	chains
1	Dihydropteroate Synthase	A,B
	ec: 2.5.1.15

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Bacillus anthracis (taxid:191218)	Anthrax	Escherichia coli (taxid:469008)
	strain: A2012 gene: folP expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Hammoudeh, D., Lee, R.E., White, S.W.

Keywords :

TIM Barrel, DHPS, DHPS inhibitors, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.1980 Å )

Citation :

Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity.

Zhao, Y.,Hammoudeh, D.,Yun, M.K. et al.
(2012) Chemmedchem 7 : 861 - 870

PDB ID: 4D8Z