Het-PDB Navi2 (PDB: 4C16)

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Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
4WC	(S)-cyclohexyl lactic acid	PoSSuM
Q6Z	(1r,2r,3s)-3-methylcyclohexane-1,2-diol	PoSSuM
GAL	Beta-D-galactopyranose	PoSSuM
FUC	Alpha-L-fucopyranose	PoSSuM

Non-standard Residues
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Glycosylation
Code	Name	Emphasize
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose

Modification
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Download interaction data: 4C16

Code :

4C16 PDBj RCSB PDB PDBe

Header :

CELL ADHESION

Title :

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonist

Release Data :

2014-08-20

Compound :

mol_id	molecule	chains	synonym
1	E-SELECTIN	A,B	CD62 ANTIGEN-LIKE FAMILY MEMBER E, ENDOTHELIAL LEUKOCYTE AD HESION MOLECULE 1, ELAM-1, LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOL ECULE 2, LECAM2
	fragment: LECTIN DOMAIN, EGF-LIKE DOMAIN, SHORT CONSENSUS REPEAT DOMAIN 1, SHORT CONSENSUS REPEAT DOMAIN 2, RESDIUES 22-301 other_details: N-ACETYLGLUCOSAMINE RESIDUES ATTACHED TO ASN4, ASN124, ASN139, ASN158, ASN178, ASN182, AND ASN244 ON BOTH CHAINS.

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	CRICETULUS GRISEUS (taxid:10029)
	tissue: CYTOKINE-INDUCED VASCULAR ENDOTHELIAL CELLS expression_system_common: CHINESE HAMSTER expression_system_tissue: OVARY expression_system_plasmid: PCDNA3.1

Authors :

Preston, R.C., Jakob, R.P., Binder, F.P.C., Sager, C.P., Ernst, B., Maier, T.

Keywords :

CELL ADHESION, CELL-ADHESION MOLECULE, C-TYPE LECTIN, INFLAMMATION, LEUKOCYTE, GLYCOMIMETIC, ANTAGONIST, CATCH- BOND

Exp. method :

X-RAY DIFFRACTION ( 1.93 Å )

Citation :

E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation.

Preston, R.C.,Jakob, R.P.,Binder, F.P. et al.
(2016) J.Mol.Cell.Biol. 8 : 62

PDB ID: 4C16