PDB ID: 4BHW
Hetero Atom Contents
color scheme of protein:
hetatm:
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information
centroid:
interaction residue:
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Code | Name | Link |
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01K | [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3r,20r)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate | PoSSuM |
ZN | Zinc ion | PoSSuM |
Download interaction data: 4BHW
Structure summary
Code : | 4BHW PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Structural basis for autoinhibition of the acetyltransferase activity of p300 | ||||||||||||
Release Data : | 2013-08-14 | ||||||||||||
Compound : |
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Source : |
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Authors : | Delvecchio, M., Gaucher, J., Aguilar-Gurrieri, C., Ortega, E., Panne, D. | ||||||||||||
Keywords : | TRANSFERASE, BROMODOMAIN, PHD DOMAIN, RING DOMAIN, HAT DOMAIN, ENHANCEOSOME | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.799 Å ) | ||||||||||||
Citation : |
Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation
Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.
et al.
PubMed: 23934153 |
Reaction
Chain : | A, B |
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UniProt : | Q09472 (EP300_HUMAN) |
Reaction : | Reaction=acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]; Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; Evidence={ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:8945521}; Reaction=(2E)-butenoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)- (2E)-butenoyl-L-lysyl-[protein]; Xref=Rhea:RHEA:53908, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:13707, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57332, ChEBI:CHEBI:137954; Evidence={ECO:0000269|PubMed:25818647}; Reaction=butanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-butanoyl- L-lysyl-[protein]; Xref=Rhea:RHEA:53912, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13708, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371, ChEBI:CHEBI:137955; Evidence={ECO:0000250|UniProtKB:B2RWS6}; Reaction=L-lysyl-[protein] + propanoyl-CoA = CoA + H(+) + N(6)- propanoyl-L-lysyl-[protein]; Xref=Rhea:RHEA:54020, Rhea:RHEA- COMP:9752, Rhea:RHEA-COMP:13758, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392, ChEBI:CHEBI:138019; Evidence={ECO:0000269|PubMed:17267393}; Reaction=2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein]; Xref=Rhea:RHEA:24180, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:15921, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:131780, ChEBI:CHEBI:144968; Evidence={ECO:0000269|PubMed:29775581}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24181; Evidence={ECO:0000269|PubMed:29775581}; |