Brand  (β version)

PDB ID: 4BHW

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Ligands
Code Name Style Show Link
01K [(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3r,20r)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 4BHW   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structural basis for autoinhibition of the acetyltransferase activity of p300
Release Data : 2013-08-14
Compound :
mol_id molecule chains synonym
1 HISTONE ACETYLTRANSFERASE P300 A,B P300 HAT, E1A-ASSOCIATED PROTEIN P300
ec: 2.3.1.48
fragment: P300 CORE, RESIDUES 1043-1519,1581-1666
mutation: YES
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN TRICHOPLUSIA NI  (taxid:7111)
expression_system_common: CABBAGE LOOPER
expression_system_cell_line: High Five
expression_system_vector_type: BACULOVIRUS
Authors : Delvecchio, M., Gaucher, J., Aguilar-Gurrieri, C., Ortega, E., Panne, D.
Keywords : TRANSFERASE, BROMODOMAIN, PHD DOMAIN, RING DOMAIN, HAT DOMAIN, ENHANCEOSOME
Exp. method : X-RAY DIFFRACTION ( 2.799 Å )
Citation :

Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation

Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.  et al.
(2013)  Nat.Struct.Mol.Biol.  20 : 1040

PubMed: 23934153
DOI: 10.1038/NSMB.2642

Reaction

Chain : A, B
UniProt : Q09472 (EP300_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+) 2.3.1.48 PubMed:14645221, PubMed:21131905, PubMed:23415232, PubMed:23934153, PubMed:25818647, PubMed:8945521
left-to-right
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+) - PubMed:15448695, PubMed:15653507, PubMed:16285960, PubMed:17761950, PubMed:22084251, PubMed:24120661, PubMed:26990986, PubMed:30197302, PubMed:32561715
left-to-right PubMed:15653507, PubMed:16285960, PubMed:15448695, PubMed:30197302, PubMed:32561715
N(6)-methyl-L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-N(6)- methyl-L-lysyl-[histone] + CoA + H(+) - PubMed:37731000
left-to-right
(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L- lysyl-[protein] + CoA + H(+) - PubMed:25818647
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butanoyl-CoA + L-lysyl-[protein] = N(6)-butanoyl-L-lysyl- [protein] + CoA + H(+) - UniProtKB:B2RWS6
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propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl- [protein] + CoA + H(+) - PubMed:17267393
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2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2- hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+) - PubMed:29775581
left-to-right
(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L- lysyl-[protein] + CoA + H(+) - PubMed:31645732
left-to-right