Het-PDB Navi2 (PDB: 3U7M)

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Ligands
Code	Name		Style	Show	Link
FHF	N-((2r,4s)-2-butyl-4-(3-(2-fluorophenyl)ureido)-5-methyl-3-oxohexyl)-N-hydroxyformamide				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
Code	Name	Show
CSD	3-sulfinoalanine

Glycosylation
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Download interaction data: 3U7M

Code :

3U7M PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

Release Data :

2012-06-27

Compound :

mol_id	molecule	chains	synonym
1	Peptide deformylase	A	PDF, Polypeptide deformylase
	ec: 3.5.1.88

Source :

mol_id	organism_scientific	expression_system
1	Staphylococcus aureus (taxid:93062)	Escherichia coli (taxid:562)
	strain: COL gene: sacol1100 expression_system_strain: C41(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET-21a(+)

Authors :

Lee, S.J., Lee, S.-J., Lee, S.K., Yoon, H.-J., Lee, H.H., Kim, K.K., Lee, B.J., Suh, S.W.

Keywords :

PDF-INHIBITOR, PDF, PEPTIDE DEFORMYLASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.15 Å )

Citation :

Structures of Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

Lee, S.J.,Lee, S.-J.,Lee, S.K. et al.
(2012) Acta Crystallogr.,Sect.D 68 : 784 - 793

Chain :

UniProt :

Q5HGZ3 (DEF_STAAC)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate	3.5.1.88	HAMAP-Rule:MF_00163
	-	HAMAP-Rule:MF_00163
Cofactor:	Evidence:	Note:
Fe(2+)	ECO:0000255 \| HAMAP-Rule:MF_00163	Binds 1 Fe(2+) ion.

PDB ID: 3U7M