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Code Name Link
CX7 Cotylenol
MG Magnesium ion
Modified Residues
Code Name Link
SEP Phosphoserine
Code : 3SP5   PDBj   RCSB PDB   PDBe
Title : Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Cotylenol
Release Data : 2016-05-04
Compound :
mol_id molecule chains synonym
1 14-3-3 protein sigma A Epithelial cell marker protein 1, Stratifin
mutation: C38V N166H
mol_id molecule chains
2 TASK-3 peptide P
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: HME1, SFN
expression_system_strain: Rosetta DE3
expression_system_vector_type: Plasmid
expression_system_plasmid: pPROEX HTB
mol_id organism_scientific
2 Homo sapiens  (taxid:9606)
synthetic: yes
other_details: This sequence occurs naturally in humans
Authors : Anders, C., Schumacher, B., Ottmann, C.
Keywords : Helical protein, Phosphoprotein, Adapter protein, Peptide binding protein
Exp. method : X-RAY DIFFRACTION ( 1.8000 Å )
Citation :

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface.

Anders, C.,Higuchi, Y.,Koschinsky, K.  et al.
(2013)  Chem.Biol.  20 : 583 - 593

PubMed: 23601647
DOI: 10.1016/j.chembiol.2013.03.015

Chain : A
UniProt : P31947 (1433S_HUMAN)
Reaction : -