Brand  (β version)

PDB ID: 3UPH

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Ligands
Code Name Style Show Link
PO4 Phosphate ion PoSSuM
0C1 6-(2,5-difluorobenzyl)-N-(methylsulfonyl)-8-(2-oxo-1,2-dihydropyridin-3-yl)-3,6-dihydro-2h-furo[2,3-E]indole-7-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3UPH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Synthesis of novel 4,5-dihydrofurano indoles and their evaluation as HCV NS5B polymerase inhibitors
Release Data : 2012-01-25
Compound :
mol_id molecule chains synonym
1 RNA-directed RNA polymerase A,B NS5B
ec: 2.7.7.48
fragment: UNP residues 2420-2989
Source :
mol_id organism_scientific organism_common expression_system
1 Hepatitis C virus  (taxid:420174) HCV Escherichia coli  (taxid:562)
strain: HC-J4
Authors : Velazquez, F., Venkataraman, S., Lesburg, C.A., Duca, J.S., Rosenblum, S.B., Kozlowski, J.A., Njoroge, F.G.
Keywords : TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors.

Velazquez, F.,Venkatraman, S.,Lesburg, C.A.  et al.
(2012)  Org.Lett.  14 : 556 - 559

PubMed: 22220815
DOI: 10.1021/ol203177g

Reaction

Chain : A, B
UniProt : O92972 (POLG_HCVJ4)
Reaction: EC: Evidence:
Physiological Direction:
[Serine protease/helicase NS3]
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'. 		3.4.21.98 UniProtKB:P27958
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[Serine protease/helicase NS3]
a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate 		3.6.1.15 UniProtKB:P27958
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[Serine protease/helicase NS3]
ATP + H2O = ADP + H(+) + phosphate 		3.6.4.13 UniProtKB:P27958
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[RNA-directed RNA polymerase]
a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) 		2.7.7.48 PROSITE-ProRule:PRU00539
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