Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
08W N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1h-imidazole-4-carboxamide
Code : 3UA8   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN/ANTAGONIST
Title : Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2
Release Data : 2012-01-11
Compound :
mol_id molecule chains synonym
1 Glutamate receptor 2 A GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
fragment: SEE REMARK 999
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GRIA2, GLUR2
expression_system_strain: DE3
expression_system_vector_type: plasmid
expression_system_plasmid: pXI472d
Authors : Kallen, J.
Keywords : ion channel, ionic channel, postsynaptic membrane, transmembrane, TRANSPORT PROTEIN-ANTAGONIST complex
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.

Orain, D.,Ofner, S.,Koller, M.  et al.
(2012)  Bioorg.Med.Chem.Lett.  22 : 996 - 999

PubMed: 22197388
DOI: 10.1016/j.bmcl.2011.12.009

Chain : A
UniProt : P42262 (GRIA2_HUMAN)
Reaction : -