Het-PDB Navi2 (PDB: 3UA8)

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Ligands
Code	Name		Style	Show	Link
08W	N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1h-imidazole-4-carboxamide				PoSSuM

Non-standard Residues
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Download interaction data: 3UA8

Code :

3UA8 PDBj RCSB PDB PDBe

Header :

TRANSPORT PROTEIN/ANTAGONIST

Title :

Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2

Release Data :

2012-01-11

Compound :

mol_id	molecule	chains	synonym
1	Glutamate receptor 2	A	GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2
	fragment: SEE REMARK 999

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GRIA2, GLUR2 expression_system_strain: DE3 expression_system_vector_type: plasmid expression_system_plasmid: pXI472d

Authors :

Kallen, J.

Keywords :

ion channel, ionic channel, postsynaptic membrane, transmembrane, TRANSPORT PROTEIN-ANTAGONIST complex

Exp. method :

X-RAY DIFFRACTION ( 1.900 Å )

Citation :

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.

Orain, D.,Ofner, S.,Koller, M. et al.
(2012) Bioorg.Med.Chem.Lett. 22 : 996 - 999

Chain :

UniProt :

P42262 (GRIA2_HUMAN)

PDB ID: 3UA8