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Ligands
Code Name Link
CSN N,4-dihydroxy-N-oxo-3-(sulfooxy)benzenaminium
Code : 3S3K   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of the catalytic domain of PTP10D from Drosophila melanogaster with a small molecular inhibitor para-NitroCatechol Sulphate
Release Data : 2011-11-02
Compound :
mol_id molecule chains synonym
1 Tyrosine-protein phosphatase 10D A,B Receptor-linked protein-tyrosine phosphatase 10D, DPTP10D
ec: 3.1.3.48
fragment: UNP residues 1250-1533
Source :
mol_id organism_scientific organism_common expression_system
1 Drosophila melanogaster  (taxid:7227) Fruit fly Escherichia coli  (taxid:562)
gene: CG1817, Ptp10D
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
Authors : Madan, L.L., Gopal, B.
Keywords : Differentiation, Neurogenesis, Signal transduction, developmental Protein, Hydrolase, Protein Phosphatase, Protein Tyrosine Phosphatase, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.20 Å )
Citation :

Conformational basis for substrate recruitment in protein tyrosine phosphatase 10D

Madan, L.L.,Gopal, B.
(2011)  Biochemistry  50 : 10114 - 10125

PubMed: 22007620
DOI: 10.1021/bi201092q

Chain : A, B
UniProt : P35992 (PTP10_DROME)
Reaction : Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044};