PDB ID: 3QRJ
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Structure summary
Code : | 3QRJ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE/TRANSFERASE INHIBITOR | ||||||||||||
Title : | The crystal structure of human abl1 kinase domain T315I mutant in complex with DCC-2036 | ||||||||||||
Release Data : | 2011-06-01 | ||||||||||||
Compound : |
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Source : |
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Authors : | Chan, W.W., Wise, S.C., Kaufman, M.D., Ahn, Y.M., Ensinger, C.L., Haack, T., Hood, M.M., Jones, J., Lord, J.W., Lu, W.P., Miller, D., Patt, W.C., Smith, B.D., Petillo, P.A., Rutkoski, T.J., Telikepalli, H., Vogeti, L., Yao, T., Chun, L., Clark, R., Evangelista, P., Gavrilescu, L.C., Lazarides, K., Zaleskas, V.M., Stewart, L.J., Van Etten, R.A., Flynn, D.L. | ||||||||||||
Keywords : | ABL1, KINASE, KINASE DOMAIN, T315I, gatekeeper mutation, TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.82 Å ) | ||||||||||||
Citation : |
Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036.
Chan, W.W.,Wise, S.C.,Kaufman, M.D.
et al.
PubMed: 21481795 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P00519 (ABL1_HUMAN) | ||||||||
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