Brand  (β version)

PDB ID: 3O4M

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CAQ Catechol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3O4M   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of porcine pancreatic phospholipase A2 in complex with 1,2-dihydroxybenzene
Release Data : 2010-08-25
Compound :
mol_id molecule chains synonym
1 Phospholipase A2, major isoenzyme A Phosphatidylcholine 2-acylhydrolase 1B, Group IB phospholipase A2
ec: 3.1.1.4
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
tissue: Pancreas
Authors : Dileep, K.V., Tintu, I., Karthe, P., Mandal, P.K., Haridas, M., Sadasivan, C.
Keywords : Catechol binding, PLA2, Pancreatic Enzyme, Disulfide bond, Lipid degradation, Lipoprotein, Metal-binding, Palmitate, Pyrrolidone carboxylic acid, Pancreas, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Binding to PLA(2) may contribute to the anti-inflammatory activity of catechol

Dileep, K.V.,Tintu, I.,Mandal, P.K.  et al.
(2011)  Chem.Biol.Drug Des. 

PubMed: 21995306
DOI: 10.1111/j.1747-0285.2011.01258.x

Reaction

Chain : A
UniProt : P00592 (PA21B_PIG)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+) 3.1.1.4 PROSITE-ProRule:PRU10035, PROSITE- ProRule:PRU10036, PubMed:17603006
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1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2- tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate - PubMed:17603006
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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate - UniProtKB:P04055
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1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+) - UniProtKB:P04054
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1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) - UniProtKB:P04055
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1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+) - UniProtKB:P04054
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H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1- (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine - UniProtKB:P04055
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1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) - UniProtKB:P04055
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H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine - UniProtKB:P04055
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