Brand  (β version)

PDB ID: 3NBY

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Ligands
Code Name Style Show Link
GTP Guanosine-5'-triphosphate PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3NBY   PDBj   RCSB PDB   PDBe
Header : GTP-binding protein/transport protein
Title : Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex
Release Data : 2010-10-27
Compound :
mol_id molecule chains synonym
1 Snurportin-1 B,E RNA U transporter 1
mol_id molecule chains synonym
2 GTP-binding nuclear protein Ran C,F GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24
mutation: Q69L
mol_id molecule chains synonym
3 Exportin-1 A,D Exp1, Chromosome region maintenance 1 protein homolog
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PKIA (GeneID: 5569) SNUPN (GeneID: 10073), RNUT1, SNUPN, SPN1
expression_system_strain: BLR
expression_system_vector_type: plasmid
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ARA24, OK/SW-cl.81, RAN, RAN (GeneID: 5901)
expression_system_strain: BLR
expression_system_vector_type: plasmid
mol_id organism_scientific organism_common expression_system
3 Mus musculus  (taxid:10090) Mouse Escherichia coli  (taxid:562)
gene: Crm1, Xpo1, Xpo1 (GeneID: 103573)
expression_system_strain: BLR
expression_system_vector_type: plasmid
Authors : Guttler, T., Madl, T., Neumann, P., Deichsel, D., Corsini, L., Monecke, T., Ficner, R., Sattler, M., Gorlich, D.
Keywords : protein transport, GTP-binding protein-transport protein complex
Exp. method : X-RAY DIFFRACTION ( 3.420 Å )
Citation :

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Guttler, T.,Madl, T.,Neumann, P.  et al.
(2010)  Nat.Struct.Mol.Biol.  17 : 1367 - 1376

PubMed: 20972448
DOI: 10.1038/nsmb.1931

Reaction

Chain : B, E
UniProt : O95149 (SPN1_HUMAN)
Reaction : -
Chain : C, F
UniProt : P62826 (RAN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - PubMed:26272610, PubMed:8636225
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:26272610
Mg(2+) interacts primarily with the phosphate groups of the bound guanine nucleotide.
Chain : A, D
UniProt : Q6P5F9 (XPO1_MOUSE)
Reaction : -