Het-PDB Navi2 (PDB: 3C4F)

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Ligands
Code	Name		Style	Show	Link
C4F	3-(3-methoxybenzyl)-1h-pyrrolo[2,3-B]pyridine				PoSSuM

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Download interaction data: 3C4F

Code :

3C4F PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole

Release Data :

2008-02-26

Compound :

mol_id	molecule	chains	synonym
1	Basic fibroblast growth factor receptor 1	A,B	FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr, CD331 antigen
	ec: 2.7.10.1 fragment: KINASE DOMAIN mutation: C488A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: FGFR1, FGFBR, FLG, FLT2 expression_system_strain: BL21(DE3)RIL expression_system_vector_type: vector expression_system_vector: pET29a

Authors :

Zhang, K.Y.J., Wang, W.

Keywords :

FIBROBLAST GROWTH FACTOR RECEPTOR, TYROSINE KINASE DOMAIN, RECEPTOR TYROSINE KINASE, FGFR1, FGFR, Alternative splicing, ATP-binding, Chromosomal rearrangement, Disease mutation, Dwarfism, Glycoprotein, Heparin-binding, Immunoglobulin domain, Kallmann syndrome, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Transferase, Transmembrane, Tyrosine-protein kinase

Exp. method :

X-RAY DIFFRACTION ( 2.07 Å )

Citation :

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

Tsai, J.,Lee, J.T.,Wang, W. et al.
(2008) Proc.Natl.Acad.Sci.Usa 105 : 3041 - 3046

PubMed: 18287029
DOI: 10.1073/pnas.0711741105

PDB ID: 3C4F

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