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Ligands
Code Name Link
CNU 5-cyano-uridine-5'-monophosphate
GOL Glycerol
SO4 Sulfate ion
Code : 3BK0   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP
Release Data : 2008-11-18
Compound :
mol_id molecule chains synonym
1 Uridine 5'-monophosphate synthase A,B UMP synthase, Orotidine 5'-phosphate decarboxylase, OMPdecase
ec: 4.1.1.23
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: UMPS
expression_system_strain: BL21(DE3)pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
Authors : Liu, Y., Tang, H.L., Avina, M.E.M., Kotra, L.P., Pai, E.F.
Keywords : UMP Synthase, C-terminal Domain, Orotidine 5'-monophosphate Decarboxylase, Human, 5-CN-UMP, Disease mutation, Glycosyltransferase, Lyase, Multifunctional enzyme, Pyrimidine biosynthesis, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP

Liu, Y.,Tang, H.L.,Avina, M.E.M.  et al.
To be Published 

Chain : A, B
UniProt : P11172 (UMPS_HUMAN)
Reaction : Reaction=diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D- ribose 1-diphosphate + orotate; Xref=Rhea:RHEA:10380, ChEBI:CHEBI:30839, ChEBI:CHEBI:33019, ChEBI:CHEBI:57538, ChEBI:CHEBI:58017; EC=2.4.2.10;
Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP; Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;