PDB ID: 3BK0
Hetero Atom Contents
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Structure summary
Code : | 3BK0 PDBj RCSB PDB PDBe | ||||||||||||
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Header : | LYASE | ||||||||||||
Title : | Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP | ||||||||||||
Release Data : | 2008-11-18 | ||||||||||||
Compound : |
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Source : |
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Authors : | Liu, Y., Tang, H.L., Avina, M.E.M., Kotra, L.P., Pai, E.F. | ||||||||||||
Keywords : | UMP Synthase, C-terminal Domain, Orotidine 5'-monophosphate Decarboxylase, Human, 5-CN-UMP, Disease mutation, Glycosyltransferase, Lyase, Multifunctional enzyme, Pyrimidine biosynthesis, Transferase | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.60 Å ) | ||||||||||||
Citation : |
Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP
Liu, Y.,Tang, H.L.,Avina, M.E.M.
et al.
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Reaction
Chain : | A, B |
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UniProt : | P11172 (UMPS_HUMAN) |
Reaction : | Reaction=diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D- ribose 1-diphosphate + orotate; Xref=Rhea:RHEA:10380, ChEBI:CHEBI:30839, ChEBI:CHEBI:33019, ChEBI:CHEBI:57538, ChEBI:CHEBI:58017; EC=2.4.2.10; Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP; Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23; |