Brand  (β version)

PDB ID: 3BK0

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Ligands
Code Name Style Show Link
CNU 5-cyano-uridine-5'-monophosphate PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3BK0   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP
Release Data : 2008-11-18
Compound :
mol_id molecule chains synonym
1 Uridine 5'-monophosphate synthase A,B UMP synthase, Orotidine 5'-phosphate decarboxylase, OMPdecase
ec: 4.1.1.23
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: UMPS
expression_system_strain: BL21(DE3)pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET15b
Authors : Liu, Y., Tang, H.L., Avina, M.E.M., Kotra, L.P., Pai, E.F.
Keywords : UMP Synthase, C-terminal Domain, Orotidine 5'-monophosphate Decarboxylase, Human, 5-CN-UMP, Disease mutation, Glycosyltransferase, Lyase, Multifunctional enzyme, Pyrimidine biosynthesis, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP

Liu, Y.,Tang, H.L.,Avina, M.E.M.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P11172 (UMPS_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
orotidine 5'-phosphate + diphosphate = orotate + 5-phospho- alpha-D-ribose 1-diphosphate 2.4.2.10 PubMed:9042911
right-to-left
orotidine 5'-phosphate + H(+) = UMP + CO2 4.1.1.23 PubMed:18184586, PubMed:9042911
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