Brand  (β version)

PDB ID: 2Y81

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Ligands
Code Name Style Show Link
931 6-chloro-N-((3s)-2-oxo-1-{4-[(2r)-2--pyrrolidinyl] phenyl}-3-pyrrolidinyl)-2-naphthalenesulfonamide PoSSuM
CA Calcium ion PoSSuM
MG Magnesium ion PoSSuM
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Structure summary

Code : 2Y81   PDBj   RCSB PDB   PDBe
Header : BLOOD CLOTTING
Title : Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs
Release Data : 2011-03-16
Compound :
mol_id molecule chains synonym
1 ACTIVATED FACTOR XA HEAVY CHAIN A COAGULATION FACTOR X, STUART FACTOR, STUART-PROWER FACTOR
ec: 3.4.21.6
other_details: DISULPHIDE LINKED TO OTHER CHAIN
mol_id molecule chains synonym
2 FACTOR X LIGHT CHAIN B COAGULATION FACTOR X, STUART FACTOR, STUART-PROWER FACTOR
ec: 3.4.21.6
fragment: ACTIVATED DESGLA, RESIDUES 46-179
other_details: DISULPHIDE LINKED TO OTHER CHAIN
Source :
mol_id organism_scientific organism_common
1 HOMO SAPIENS  (taxid:9606) HUMAN
other_details: PURCHASED FROM ENZYME RESEARCH LABS. ISOLATED FROM HUMAN BLOOD
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
other_details: PURCHASED FROM ENZYME RESEARCH LABS. ISOLATED FROM HUMAN BLOOD
Authors : Young, R.J., Adams, C., Blows, M., Brown, D., Burns-Kurtis, C.L., Chaudry, L., Chan, C., Convery, M.A., Davies, D.E., Exall, A.M., Foster, G., Harling, J.D., Hortense, E., Irving, W.R., Irvine, S., Jackson, S., Kleanthous, S., Pateman, A.J., Patikis, A.N., Roethka, T.J., Senger, S., Stelman, G.J., Toomey, J.R., West, R.I., Whittaker, C., Zhou, P., Watson, N.S.
Keywords : BLOOD CLOTTING, HYDROLASE, SERINE PROTEASE, BLOOD COAGULATION PROTEASE
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Aminoindane and Phenylpyrrolidine P4 Motifs.

Young, R.J.,Adams, C.,Blows, M.  et al.
(2011)  Bioorg.Med.Chem.Lett.  21 : 1582

PubMed: 21349710
DOI: 10.1016/J.BMCL.2011.01.131

Reaction

Chain : B
UniProt : P00742 (FA10_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. 3.4.21.6 -
-