Brand  (β version)

PDB ID: 2UZN

Hetero Atom Contents

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
C96 4-{5-[(1z)-1-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)ethyl]-2-furyl}benzenesulfonamide PoSSuM

Structure summary

Code : 2UZN   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor
Release Data : 2007-06-26
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A P33 PROTEIN KINASE, CYCLIN DEPENDENT KINASE 2
ec: 2.7.11.22, 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_strain: SF21
expression_system_vector_type: BACULOVIRUS
Authors : Richardson, C.M., Dokurno, P., Murray, J.B., Surgenor, A.E.
Keywords : TRANSFERASE, ATP-BINDING, PHOSPHORYLATION, CDK2, KINASE, CYCLIN, MITOSIS, CELL CYCLE, CELL DIVISION, NUCLEOTIDE-BINDING, SERINE/THREONINE-PROTEIN KINASE, THIAZOLIDINONE LIGAND
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Discovery of a Potent Cdk2 Inhibitor with a Novel Binding Mode, Using Virtual Screening and Initial, Structure-Guided Lead Scoping.

Richardson, C.M.,Nunns, C.L.,Williamson, D.S.  et al.
(2007)  Bioorg.Med.Chem.Lett.  17 : 3880

PubMed: 17570665
DOI: 10.1016/J.BMCL.2007.04.110

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction : Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:9030781};
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.22; Evidence={ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:28666995, ECO:0000269|PubMed:9030781};